Long-lifetime lipid rhenium metal-ligand complex for probing membrane dynamics on the microsecond timescale

Li Li, Felix N. Castellano, Ignacy Gryczynski, Joseph R. Lakowicz

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We report the luminescence and spectral properties of a phospholipid analogue containing a long-lifetime luminescent rhenium metal-ligand complex (MLC) covalently linked to the amino group of phosphatidyl ethanolamine. When incorporated into synthetic membranes, this lipid probe displays intensity decay times near 3 μs. Importantly, the probe displays highly polarized emission with a maximal fundamental anisotropy of 0.33. This probe is expected to have numerous applications for studies of microsecond diffusion and dynamics of membranes. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalChemistry and Physics of Lipids
Volume99
Issue number1
DOIs
StatePublished - May 1999

Keywords

  • Long-lifetime lipid
  • Membrane dynamics
  • Rhenium metal-ligand complex

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