TY - JOUR
T1 - Livedoid Vasculopathy Presenting in a Patient With Sickle Cell Disease
AU - Reagin, Heather
AU - Marks, Etan
AU - Weis, Stephen
AU - Susa, Joseph
PY - 2018/9/1
Y1 - 2018/9/1
N2 - We report a case in which a 43-year-old African American male with medical history of sickle cell disease (SCD) presented with a nonhealing ulcer. Biopsy revealed features of livedoid vasculopathy. Previously, livedoid vasculopathy had only been described in a patient with sickle cell trait, but never in a patient with SCD. Livedoid vasculopathy most commonly affects the distal lower extremities and is characterized by irregular, punched-out, painful ulcers that heal with stellate white scars of atrophie blanche. Histologically, it reveals segmental hyalinizing vessels, focal thrombosis, and endothelial proliferation. The etiology is currently unclear, but it has been shown to be related to procoagulant states and a diagnosis of livedoid vasculopathy should prompt a thorough hypercoagulable workup, including testing for SCD in high-risk patients.
AB - We report a case in which a 43-year-old African American male with medical history of sickle cell disease (SCD) presented with a nonhealing ulcer. Biopsy revealed features of livedoid vasculopathy. Previously, livedoid vasculopathy had only been described in a patient with sickle cell trait, but never in a patient with SCD. Livedoid vasculopathy most commonly affects the distal lower extremities and is characterized by irregular, punched-out, painful ulcers that heal with stellate white scars of atrophie blanche. Histologically, it reveals segmental hyalinizing vessels, focal thrombosis, and endothelial proliferation. The etiology is currently unclear, but it has been shown to be related to procoagulant states and a diagnosis of livedoid vasculopathy should prompt a thorough hypercoagulable workup, including testing for SCD in high-risk patients.
KW - Livedoid vasculopathy
KW - atrophie blanche
KW - leg ulcers
KW - livedoid vasculitis
KW - sickle cell disease
UR - http://www.scopus.com/inward/record.url?scp=85057164455&partnerID=8YFLogxK
U2 - 10.1097/DAD.0000000000001133
DO - 10.1097/DAD.0000000000001133
M3 - Article
C2 - 29533274
AN - SCOPUS:85057164455
SN - 0193-1091
VL - 40
SP - 682
EP - 685
JO - The American Journal of dermatopathology
JF - The American Journal of dermatopathology
IS - 9
ER -