Lipoproteins for therapeutic delivery: Recent advances and future opportunities

Sangram Raut, Jean Louis Dasseux, Nirupama A. Sabnis, Linda Mooberry, Andras Lacko

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.

Original languageEnglish
Pages (from-to)257-268
Number of pages12
JournalTherapeutic Delivery
Volume9
Issue number4
DOIs
StatePublished - 1 Jan 2018

Keywords

  • HDL
  • LDL
  • cancer therapy
  • discoidal nanoparticles
  • drug delivery
  • lipoproteins
  • rHDL

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