Lipoproteins for therapeutic delivery

Recent advances and future opportunities

Sangram Limbaji Raut, Jean Louis Dasseux, Nirupama A. Sabnis, Linda Mooberry, Andras G. Lacko

Research output: Contribution to journalReview articleResearchpeer-review

2 Citations (Scopus)

Abstract

The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.

Original languageEnglish
Pages (from-to)257-268
Number of pages12
JournalTherapeutic Delivery
Volume9
Issue number4
DOIs
StatePublished - 1 Jan 2018

Fingerprint

Lipoproteins
Neoplasms
Triglycerides
Therapeutics
Cholesterol
Pharmaceutical Preparations

Keywords

  • HDL
  • LDL
  • cancer therapy
  • discoidal nanoparticles
  • drug delivery
  • lipoproteins
  • rHDL

Cite this

Raut, Sangram Limbaji ; Dasseux, Jean Louis ; Sabnis, Nirupama A. ; Mooberry, Linda ; Lacko, Andras G. / Lipoproteins for therapeutic delivery : Recent advances and future opportunities. In: Therapeutic Delivery. 2018 ; Vol. 9, No. 4. pp. 257-268.
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Lipoproteins for therapeutic delivery : Recent advances and future opportunities. / Raut, Sangram Limbaji; Dasseux, Jean Louis; Sabnis, Nirupama A.; Mooberry, Linda; Lacko, Andras G.

In: Therapeutic Delivery, Vol. 9, No. 4, 01.01.2018, p. 257-268.

Research output: Contribution to journalReview articleResearchpeer-review

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