Lipoproteins for therapeutic delivery: Recent advances and future opportunities

Sangram Raut; Jean Louis Dasseux; Nirupama A. Sabnis; Linda Mooberry; Andras Lacko

doi:10.4155/tde-2017-0122

Lipoproteins for therapeutic delivery: Recent advances and future opportunities

Sangram Raut, Jean Louis Dasseux, Nirupama A. Sabnis, Linda Mooberry, Andras Lacko

Physiology & Anatomy

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.

Original language	English
Pages (from-to)	257-268
Number of pages	12
Journal	Therapeutic Delivery
Volume	9
Issue number	4
DOIs	https://doi.org/10.4155/tde-2017-0122
State	Published - 1 Jan 2018

Keywords

HDL
LDL
cancer therapy
discoidal nanoparticles
drug delivery
lipoproteins
rHDL

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10.4155/tde-2017-0122

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title = "Lipoproteins for therapeutic delivery: Recent advances and future opportunities",

abstract = "The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.",

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AU - Mooberry, Linda

AU - Lacko, Andras

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AB - The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.

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KW - LDL

KW - cancer therapy

KW - discoidal nanoparticles

KW - drug delivery

KW - lipoproteins

KW - rHDL

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