Abstract
The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 257-268 |
| Number of pages | 12 |
| Journal | Therapeutic Delivery |
| Volume | 9 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 Jan 2018 |
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Keywords
- HDL
- LDL
- cancer therapy
- discoidal nanoparticles
- drug delivery
- lipoproteins
- rHDL
Cite this
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Lipoproteins for therapeutic delivery : Recent advances and future opportunities. / Raut, Sangram; Dasseux, Jean Louis; Sabnis, Nirupama A.; Mooberry, Linda; Lacko, Andras.
In: Therapeutic Delivery, Vol. 9, No. 4, 01.01.2018, p. 257-268.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Lipoproteins for therapeutic delivery
T2 - Recent advances and future opportunities
AU - Raut, Sangram
AU - Dasseux, Jean Louis
AU - Sabnis, Nirupama A.
AU - Mooberry, Linda
AU - Lacko, Andras
PY - 2018/1/1
Y1 - 2018/1/1
N2 - The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.
AB - The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their advantageous payload capacity, long residence time in the circulation and biocompatibility. The purpose of this review is to briefly discuss current findings with the focus on each type of formulation's potential for clinical applications. Regarding utilizing lipoprotein type formulation for cancer therapeutics, their potential for tumor-selective delivery is also discussed.
KW - HDL
KW - LDL
KW - cancer therapy
KW - discoidal nanoparticles
KW - drug delivery
KW - lipoproteins
KW - rHDL
UR - http://www.scopus.com/inward/record.url?scp=85043983397&partnerID=8YFLogxK
U2 - 10.4155/tde-2017-0122
DO - 10.4155/tde-2017-0122
M3 - Review article
C2 - 29495929
AN - SCOPUS:85043983397
VL - 9
SP - 257
EP - 268
JO - Therapeutic Delivery
JF - Therapeutic Delivery
SN - 2041-5990
IS - 4
ER -