Lipids and adipokines as risk factors for Alzheimer's disease

Matthew W. Warren; Linda S. Hynan; Myron F. Weiner; Rachelle Doody; Susan Rountree; Violeta Capriles; Christie Ballantyne; Eveleen Darby; Tracy Dawson; Aline Hittle; Aisha Khaleeg; Sid O'Bryant; Paula Grammas; Benjamin Williams; Chuang Kuo Wu; Yan Zhang; Gregory Schrimsher; Andrew Dentino; Parastoo Momeni; Larry Hill; Thomas J. Fairchild; Janice Knebl; Robert Barber; Douglas Mains; Lisa Alvarez; Perrie Adams; Roger Rosenberg; Joan Reisch; Ryan Huebinger; Doris Svetlik; Janet Smith Mechelle Murray; Tomequa Sears; Donald Royall; Helen Hazuda; Raymond Palmer; Marsha Polk

doi:10.3233/JAD-2012-111385

Lipids and adipokines as risk factors for Alzheimer's disease

Matthew W. Warren, Linda S. Hynan, Myron F. Weiner, Rachelle Doody, Susan Rountree, Violeta Capriles, Christie Ballantyne, Eveleen Darby, Tracy Dawson, Aline Hittle, Aisha Khaleeg, Sid O'Bryant, Paula Grammas, Benjamin Williams, Chuang Kuo Wu, Yan Zhang, Gregory Schrimsher, Andrew Dentino, Parastoo Momeni, Larry HillThomas J. Fairchild, Janice Knebl, Robert Barber, Douglas Mains, Lisa Alvarez, Perrie Adams, Roger Rosenberg, Joan Reisch, Ryan Huebinger, Doris Svetlik, Janet Smith Mechelle Murray, Tomequa Sears, Donald Royall, Helen Hazuda, Raymond Palmer, Marsha Polk

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.

Original language	English
Pages (from-to)	151-157
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	29
Issue number	1
DOIs	https://doi.org/10.3233/JAD-2012-111385
State	Published - 2012

Keywords

Adiponectin
Alzheimer's disease
cholesterol
leptin

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10.3233/JAD-2012-111385

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Warren, M. W., Hynan, L. S., Weiner, M. F., Doody, R., Rountree, S., Capriles, V., Ballantyne, C., Darby, E., Dawson, T., Hittle, A., Khaleeg, A., O'Bryant, S., Grammas, P., Williams, B., Wu, C. K., Zhang, Y., Schrimsher, G., Dentino, A., Momeni, P., ... Polk, M. (2012). Lipids and adipokines as risk factors for Alzheimer's disease. Journal of Alzheimer's Disease, 29(1), 151-157. https://doi.org/10.3233/JAD-2012-111385

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title = "Lipids and adipokines as risk factors for Alzheimer's disease",

abstract = "To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.",

keywords = "Adiponectin, Alzheimer's disease, cholesterol, leptin",

author = "Warren, {Matthew W.} and Hynan, {Linda S.} and Weiner, {Myron F.} and Rachelle Doody and Susan Rountree and Violeta Capriles and Christie Ballantyne and Eveleen Darby and Tracy Dawson and Aline Hittle and Aisha Khaleeg and Sid O'Bryant and Paula Grammas and Benjamin Williams and Wu, {Chuang Kuo} and Yan Zhang and Gregory Schrimsher and Andrew Dentino and Parastoo Momeni and Larry Hill and Fairchild, {Thomas J.} and Janice Knebl and Robert Barber and Douglas Mains and Lisa Alvarez and Perrie Adams and Roger Rosenberg and Joan Reisch and Ryan Huebinger and Doris Svetlik and Murray, {Janet Smith Mechelle} and Tomequa Sears and Donald Royall and Helen Hazuda and Raymond Palmer and Marsha Polk",

year = "2012",

doi = "10.3233/JAD-2012-111385",

language = "English",

volume = "29",

pages = "151--157",

journal = "Journal of Alzheimer's Disease",

issn = "1387-2877",

publisher = "IOS Press",

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Warren, MW, Hynan, LS, Weiner, MF, Doody, R, Rountree, S, Capriles, V, Ballantyne, C, Darby, E, Dawson, T, Hittle, A, Khaleeg, A, O'Bryant, S, Grammas, P, Williams, B, Wu, CK, Zhang, Y, Schrimsher, G, Dentino, A, Momeni, P, Hill, L, Fairchild, TJ, Knebl, J , Barber, R, Mains, D, Alvarez, L, Adams, P, Rosenberg, R, Reisch, J, Huebinger, R, Svetlik, D, Murray, JSM, Sears, T, Royall, D, Hazuda, H, Palmer, R & Polk, M 2012, 'Lipids and adipokines as risk factors for Alzheimer's disease', Journal of Alzheimer's Disease, vol. 29, no. 1, pp. 151-157. https://doi.org/10.3233/JAD-2012-111385

TY - JOUR

T1 - Lipids and adipokines as risk factors for Alzheimer's disease

AU - Warren, Matthew W.

AU - Hynan, Linda S.

AU - Weiner, Myron F.

AU - Doody, Rachelle

AU - Rountree, Susan

AU - Capriles, Violeta

AU - Ballantyne, Christie

AU - Darby, Eveleen

AU - Dawson, Tracy

AU - Hittle, Aline

AU - Khaleeg, Aisha

AU - O'Bryant, Sid

AU - Grammas, Paula

AU - Williams, Benjamin

AU - Wu, Chuang Kuo

AU - Zhang, Yan

AU - Schrimsher, Gregory

AU - Dentino, Andrew

AU - Momeni, Parastoo

AU - Hill, Larry

AU - Fairchild, Thomas J.

AU - Knebl, Janice

AU - Barber, Robert

AU - Mains, Douglas

AU - Alvarez, Lisa

AU - Adams, Perrie

AU - Rosenberg, Roger

AU - Reisch, Joan

AU - Huebinger, Ryan

AU - Svetlik, Doris

AU - Murray, Janet Smith Mechelle

AU - Sears, Tomequa

AU - Royall, Donald

AU - Hazuda, Helen

AU - Palmer, Raymond

AU - Polk, Marsha

PY - 2012

Y1 - 2012

N2 - To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.

AB - To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.

KW - Adiponectin

KW - Alzheimer's disease

KW - cholesterol

KW - leptin

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U2 - 10.3233/JAD-2012-111385

DO - 10.3233/JAD-2012-111385

M3 - Article

C2 - 22232009

AN - SCOPUS:84863229451

SN - 1387-2877

VL - 29

SP - 151

EP - 157

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

IS - 1

ER -

Lipids and adipokines as risk factors for Alzheimer's disease

Abstract

Keywords

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