Lipids and adipokines as risk factors for Alzheimer's disease

Matthew W. Warren, Linda S. Hynan, Myron F. Weiner, Rachelle Doody, Susan Rountree, Violeta Capriles, Christie Ballantyne, Eveleen Darby, Tracy Dawson, Aline Hittle, Aisha Khaleeg, Sid O'Bryant, Paula Grammas, Benjamin Williams, Chuang Kuo Wu, Yan Zhang, Gregory Schrimsher, Andrew Dentino, Parastoo Momeni, Larry HillThomas Fairchild, Janice Knebl, Robert Barber, Douglas Mains, Lisa Alvarez, Perrie Adams, Roger Rosenberg, Joan Reisch, Ryan Huebinger, Doris Svetlik, Janet Smith Mechelle Murray, Tomequa Sears, Donald Royall, Helen Hazuda, Raymond Palmer, Marsha Polk

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

To determine if measures of adipokines and other blood lipids differentiate between normal controls and persons with Alzheimer's disease (AD), we examined levels of leptin, adiponectin, total cholesterol, high density lipoproteins (HDL), calculated low density lipoproteins (LDL), triglycerides and apolipoprotein E allele status in 148 early AD subjects and 198 normal controls. We were unable to demonstrate a significant difference between leptin and adiponectin levels between normal controls and AD subjects. We were able to confirm observations of lower HDL and higher total and LDL cholesterol concentration in AD subjects than in controls. As expected, the presence of the apolipoprotein E4 allele distinguished between the two groups.

Original languageEnglish
Pages (from-to)151-157
Number of pages7
JournalJournal of Alzheimer's Disease
Volume29
Issue number1
DOIs
StatePublished - 2012

Keywords

  • Adiponectin
  • Alzheimer's disease
  • cholesterol
  • leptin

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    Warren, M. W., Hynan, L. S., Weiner, M. F., Doody, R., Rountree, S., Capriles, V., Ballantyne, C., Darby, E., Dawson, T., Hittle, A., Khaleeg, A., O'Bryant, S., Grammas, P., Williams, B., Wu, C. K., Zhang, Y., Schrimsher, G., Dentino, A., Momeni, P., ... Polk, M. (2012). Lipids and adipokines as risk factors for Alzheimer's disease. Journal of Alzheimer's Disease, 29(1), 151-157. https://doi.org/10.3233/JAD-2012-111385