Linkage, recombination, and mutation rate analyses of 19 X-chromosomal STR loci in Chinese Southern Han pedigrees

Xingyi Yang, Yutian Chen, Xiangpei Zeng, Ling Chen, Changhui Liu, Hong Liu, Quyi Xu, Bruce Budowle, Chao Liu

Research output: Contribution to journalArticle


From Southern Han Chinese samples, we analyzed 19 X-STR markers for linkage, linkage disequilibrium (LD), and mutation rate. The data were collected from two- and three-generation Southern Han Chinese families. These data suggested that both linkage and linkage disequilibrium should be considered while calculating likelihood ratios with X-STR markers in relationship tests. The linkage disequilibrium of these 19 X-STR markers was calculated in our previous research study that was conducted on Southern Han Chinese population. In this study, the recombination fractions between pairs of markers and those obtained from the second-generation Rutgers combined linkage-physical map of the human genome were compared. The observed differences indicated that recombination was not homogeneous along the X chromosome. Therefore, we evaluated the effect on likelihood calculations by referring to haplotype frequencies obtained from allele distributions rather than haplotype counts of Southern Han Chinese population.

Original languageEnglish
Pages (from-to)1691-1698
Number of pages8
JournalInternational journal of legal medicine
Issue number6
Publication statusPublished - 1 Nov 2019



  • Han Chinese
  • Linkage
  • Linkage disequilibrium
  • Mutation
  • X STRs

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