Linkage disequilibria and haplotype structure of four SNPs of the interleukin 1 gene cluster in seven Asian Indian populations

Srilakshmi M. Raj, Ranajit Chakraborty, Ning Wang, Diddahally R. Govindaraju

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Variation at four single nucleotide polymorphism (SNP) sites of the interleukin 1 (IL1) gene cluster was investigated among 280 unrelated individuals, representing 7 caste groups from the state of Karnataka, India, and one European American community of Boston, Massachusetts. Allele and haplotype frequencies, strength of linkage disequilibrium, and signatures of recombination varied considerably among populations. Variable community sizes and traditions of consanguinity may account for the observed variation.

Original languageEnglish
Pages (from-to)109-119
Number of pages11
JournalHuman Biology
Volume78
Issue number1
DOIs
StatePublished - Feb 2006

Keywords

  • Boston European American population
  • Cardiovascular disease
  • Caste groups
  • India
  • Interleukin 1 (IL1) gene cluster

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