Leptin produced by obese adipose stromal/stem cells enhances proliferation and metastasis of estrogen receptor positive breast cancers

Keyphrases

• Leptin 100%
• Metastasis 100%
• Stromal Stem Cells 100%
• Estrogen Receptor-positive Breast Cancer 100%
• Short Hairpin RNA (shRNA) 66%
• Breast Cancer Cells 33%
• MCF-7 Cells 25%
• Obesity 25%
• Cancer Cell Growth 25%
• Obese Women 25%
• Tumor 16%
• Breast Cancer 16%
• Matrix metalloproteinase-2 (MMP-2) 16%
• Direct Co-culture 16%
• Estrogen Receptor-positive 16%
• SERPINE1 16%
• Knockdown 8%
• Interleukin-6 8%
• Gene Expression 8%
• Adipose Tissue 8%
• Liver 8%
• Enhanced Expression 8%
• Lung 8%
• Reduced Expression 8%
• Mechanistic Insight 8%
• Proliferation Migration 8%
• Cell Progression 8%
• Migration Invasion 8%
• Epithelial-to-mesenchymal Transition 8%
• Cancer Cell Proliferation 8%
• Metastatic Lesions 8%
• Aggressiveness 8%
• Tumor Volume 8%
• Metastatic Breast Cancer 8%
• SCID Mice 8%
• Proliferative Effect 8%
• Direct Impact 8%
• Leptin Expression 8%
• Breast Cancer Cell Proliferation 8%
• Tumorigenicity 8%
• Adiposity 8%
• Leptin Secretion 8%
• Proliferation Genes 8%
• Lean Women 8%
• Gene Induction 8%

Biochemistry, Genetics and Molecular Biology

• Estrogen Receptor 100%
• Stem Cell 100%
• Leptin 100%
• Small Hairpin RNA 57%
• Cancer Cell 42%
• Cell Growth 21%
• Cell Proliferation 14%
• Gelatinase A 14%
• MMP2 14%
• Coculture 14%
• Secretion (Process) 7%
• Gene Expression 7%
• Interleukin-6 7%
• Mesenchymal-Epithelial Transition 7%
• Tumor Volume 7%
• Gene Induction 7%
• SCID Beige Mouse 7%

Pharmacology, Toxicology and Pharmaceutical Science

• Leptin 100%
• Estrogen Receptor Positive Breast Cancer 100%
• Short Hairpin RNA 57%
• Breast Cancer 42%
• Cancer Growth 21%
• Neoplasm 21%
• Estrogen Receptor 14%
• Gelatinase A 14%
• Malignant Neoplasm 7%
• Obesity 7%
• SCID Beige Mouse 7%
• Carcinogenicity 7%