TY - JOUR
T1 - Leptin and mechanisms of endothelial dysfunction and cardiovascular disease.
AU - Knudson, Jarrod D.
AU - Payne, Gregory A.
AU - Borbouse, Léna
AU - Tune, Johnathan D.
PY - 2008/12
Y1 - 2008/12
N2 - Leptin, a product of the obesity gene, is a molecule that has received much attention since its cloning in 1994. Initially, most work centered around the effects of leptin on satiety and energy balance. However, in recent years there has been an intense focus on leptin as it relates to the cardiovascular system. Plasma leptin concentration is markedly elevated in obesity and the metabolic syndrome, both of which are associated with increased incidence of cardiovascular pathologies. In many studies, hyperleptinemia has been linked to endothelial dysfunction (a known precursor to atherosclerotic cardiovascular disease) and activation of the sympathetic nervous system. Additionally, recent evidence suggests that leptin released from perivascular adipose tissue may also have deleterious effects on the underlying vasculature, including the coronary circulation. This report reviews pertinent literature on leptin-mediated endothelial dysfunction, leptin-mediated sympathetic activation, and leptin as a significant perivascular adipose-derived factor.
AB - Leptin, a product of the obesity gene, is a molecule that has received much attention since its cloning in 1994. Initially, most work centered around the effects of leptin on satiety and energy balance. However, in recent years there has been an intense focus on leptin as it relates to the cardiovascular system. Plasma leptin concentration is markedly elevated in obesity and the metabolic syndrome, both of which are associated with increased incidence of cardiovascular pathologies. In many studies, hyperleptinemia has been linked to endothelial dysfunction (a known precursor to atherosclerotic cardiovascular disease) and activation of the sympathetic nervous system. Additionally, recent evidence suggests that leptin released from perivascular adipose tissue may also have deleterious effects on the underlying vasculature, including the coronary circulation. This report reviews pertinent literature on leptin-mediated endothelial dysfunction, leptin-mediated sympathetic activation, and leptin as a significant perivascular adipose-derived factor.
UR - http://www.scopus.com/inward/record.url?scp=58949091779&partnerID=8YFLogxK
U2 - 10.1007/s11906-008-0082-2
DO - 10.1007/s11906-008-0082-2
M3 - Review article
C2 - 18959828
AN - SCOPUS:58949091779
SN - 1522-6417
VL - 10
SP - 434
EP - 439
JO - Current Hypertension Reports
JF - Current Hypertension Reports
IS - 6
ER -