Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Keyphrases

• Intraocular Pressure 100%
• Glaucoma 100%
• Mouse Model 100%
• Myocilin 100%
• Cas9 Protein 100%
• Lentiviral 100%
• Trabecular Meshwork 54%
• Lentivirus 54%
• Endoplasmic Reticulum Stress (ER stress) 18%
• Trabecular Meshwork Cells 18%
• Intravitreal Injection 18%
• Adenovirus Type 5 18%
• Adenovirus 18%
• Intracameral Injection 18%
• GFP Expression 18%
• Primary Open-angle Glaucoma 9%
• Cell Death 9%
• Endoplasmic Reticulum 9%
• Retina 9%
• Elevated IOP 9%
• Knock 9%
• Clinical Application 9%
• Intravitreal 9%
• Ciliary Body 9%
• Stably Expressing 9%
• Virus Serotype 9%
• Myocilin Gene 9%
• Genetic Causes 9%
• Gain-of-function 9%
• MiRNA Target 9%
• Tropism 9%
• Gene Editing 9%
• CRISPR/Cas9 Genome Editing 9%
• Guide RNA (gRNA) 9%
• Lentiviral Particle 9%

Immunology and Microbiology

• Intraocular Pressure 100%
• Mouse Model 100%
• Trabecular Meshwork 100%
• CRISPR/Cas9 100%
• Lentivirus 75%
• Endoplasmic Reticulum Stress 25%
• Gene Editing 25%
• Human Adenovirus 5 25%
• Adeno Associated Virus 25%
• Endoplasmic reticulum 12%
• Cell Death 12%
• Serotype 12%
• Ciliary Body 12%
• Ribonucleic Acid 12%

Biochemistry, Genetics and Molecular Biology

• Intraocular Pressure 100%
• Mouse Model 100%
• CRISPR/Cas9 100%
• Lentivirus 100%
• Endoplasmic Reticulum Stress 33%
• Human Adenovirus 5 33%
• Adeno Associated Virus 33%
• Genetics 16%
• Cell Death 16%
• Genome Editing 16%
• Cas9 16%
• Serotype 16%
• Guide RNA 16%
• Genome Editing 16%