Length variation in HV2 of the human mitochondrial DNA control region

J. E. Stewart; C. L. Fisher; P. J. Aagaard; M. R. Wilson; A. R. Isenberg; D. Polanskey; E. Pokorak; J. A. Dizinno; B. Budowle

doi:10.1520/jfs15059j

Length variation in HV2 of the human mitochondrial DNA control region

J. E. Stewart, C. L. Fisher, P. J. Aagaard, M. R. Wilson, A. R. Isenberg, D. Polanskey, E. Pokorak, J. A. Dizinno, B. Budowle

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51 Scopus citations

Abstract

Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.

Original language	English
Pages (from-to)	862-870
Number of pages	9
Journal	Journal of Forensic Sciences
Volume	46
Issue number	4
DOIs	https://doi.org/10.1520/jfs15059j
State	Published - 2001

Keywords

C-stretch
Forensic science
Length heteroplasmy
Mitochondrial DNA

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title = "Length variation in HV2 of the human mitochondrial DNA control region",

abstract = "Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.",

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doi = "10.1520/jfs15059j",

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TY - JOUR

T1 - Length variation in HV2 of the human mitochondrial DNA control region

AU - Stewart, J. E.

AU - Fisher, C. L.

AU - Aagaard, P. J.

AU - Wilson, M. R.

AU - Isenberg, A. R.

AU - Polanskey, D.

AU - Pokorak, E.

AU - Dizinno, J. A.

AU - Budowle, B.

PY - 2001

Y1 - 2001

N2 - Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.

AB - Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.

KW - C-stretch

KW - Forensic science

KW - Length heteroplasmy

KW - Mitochondrial DNA

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SP - 862

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JF - Journal of forensic sciences

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Length variation in HV2 of the human mitochondrial DNA control region

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