Length variation in HV2 of the human mitochondrial DNA control region

J. E. Stewart, C. L. Fisher, P. J. Aagaard, M. R. Wilson, A. R. Isenberg, D. Polanskey, E. Pokorak, J. A. Dizinno, B. Budowle

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.

Original languageEnglish
Pages (from-to)862-870
Number of pages9
JournalJournal of Forensic Sciences
Issue number4
StatePublished - 2001


  • C-stretch
  • Forensic science
  • Length heteroplasmy
  • Mitochondrial DNA


Dive into the research topics of 'Length variation in HV2 of the human mitochondrial DNA control region'. Together they form a unique fingerprint.

Cite this