Length variation in HV2 of the human mitochondrial DNA control region

J. E. Stewart, C. L. Fisher, P. J. Aagaard, M. R. Wilson, A. R. Isenberg, D. Polanskey, E. Pokorak, J. A. Dizinno, B. Budowle

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Abstract

Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.

Original languageEnglish
Pages (from-to)862-870
Number of pages9
JournalJournal of Forensic Sciences
Volume46
Issue number4
DOIs
StatePublished - 2001

Keywords

  • C-stretch
  • Forensic science
  • Length heteroplasmy
  • Mitochondrial DNA

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    Stewart, J. E., Fisher, C. L., Aagaard, P. J., Wilson, M. R., Isenberg, A. R., Polanskey, D., Pokorak, E., Dizinno, J. A., & Budowle, B. (2001). Length variation in HV2 of the human mitochondrial DNA control region. Journal of Forensic Sciences, 46(4), 862-870. https://doi.org/10.1520/jfs15059j