TY - JOUR
T1 - Lecithin
T2 - cholesterol acyltransferase in Down's syndrome
AU - Lacko, Andras G.
AU - Hayes, James D.
AU - McConathy, Walter J.
AU - Lacko, Irene
AU - Redheendran, R.
N1 - Funding Information:
We thank J. Fesmire for excellent technical assistance and K. Weber and I. Sharma for assisting with the statistical analyses. This study was supported by grants from the National Institutes of Health (AG-03255, BRSG 507 RR07195, HL-2318 1 and HL-23719). The American Heart Association (82-1043) and The Robert A. Welch Foundation (B-935).
PY - 1983/8/15
Y1 - 1983/8/15
N2 - Based on earlier reports indicating that Down's syndrome may represent an atheroma-free human model, two groups of institutionalized subjects were compared with respect to various parameters of their plasma lipid transport system. One group of subjects was comprised of Down's syndrome subjects and the second, a group of mentally retarded individuals. Parameters measured included plasma cholesterol, triglyceride, HDL-cholesterol, apolipoprotein levels (A-I, B, C-III, and E), lecithin: cholesterol acyltransferase (LCAT) activity, body mass and blood pressure. Statistical analyses indicated no significant differences between the two groups except for the lower fractional rate of cholesterol esterification (% cholesterol esterified per hour, p = 0.0049) in the Down's syndrome subjects. Adjustment for the effects of body mass and age revealed no other significant differences between the two groups except for a lower molar rate of esterification (nmol cholesterol esterified · h-1, p < 0.0063) in the Down's syndrome subjects. Additional differences between the two groups were revealed by partial correlational analyses of LCAT activity with the measured parameters or ratios of these parameters which suggests that the composition and/or metabolism of lipoproteins may differ between these two groups. Whether the lower LCAT activity and the other differences reflected by the correlational analyses contribute to the decreased incidence of atherosclerotic lesions in Down's syndrome remains to be elucidated.
AB - Based on earlier reports indicating that Down's syndrome may represent an atheroma-free human model, two groups of institutionalized subjects were compared with respect to various parameters of their plasma lipid transport system. One group of subjects was comprised of Down's syndrome subjects and the second, a group of mentally retarded individuals. Parameters measured included plasma cholesterol, triglyceride, HDL-cholesterol, apolipoprotein levels (A-I, B, C-III, and E), lecithin: cholesterol acyltransferase (LCAT) activity, body mass and blood pressure. Statistical analyses indicated no significant differences between the two groups except for the lower fractional rate of cholesterol esterification (% cholesterol esterified per hour, p = 0.0049) in the Down's syndrome subjects. Adjustment for the effects of body mass and age revealed no other significant differences between the two groups except for a lower molar rate of esterification (nmol cholesterol esterified · h-1, p < 0.0063) in the Down's syndrome subjects. Additional differences between the two groups were revealed by partial correlational analyses of LCAT activity with the measured parameters or ratios of these parameters which suggests that the composition and/or metabolism of lipoproteins may differ between these two groups. Whether the lower LCAT activity and the other differences reflected by the correlational analyses contribute to the decreased incidence of atherosclerotic lesions in Down's syndrome remains to be elucidated.
UR - http://www.scopus.com/inward/record.url?scp=0020628946&partnerID=8YFLogxK
U2 - 10.1016/0009-8981(83)90241-3
DO - 10.1016/0009-8981(83)90241-3
M3 - Article
C2 - 6225568
AN - SCOPUS:0020628946
SN - 0009-8981
VL - 132
SP - 133
EP - 141
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 2
ER -