Key signaling pathways in aging and potential interventions for healthy aging

Mengdi Yu, Hongxia Zhang, Brian Wang, Yinuo Zhang, Xiaoying Zheng, Bei Shao, Qichuan Zhuge, Kunlin Jin

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Aging is a fundamental biological process accompanied by a general decline in tissue function. Indeed, as the lifespan increases, age-related dysfunction, such as cognitive impairment or dementia, will become a growing public health issue. Aging is also a great risk factor for many age-related diseases. Nowadays, people want not only to live longer but also healthier. Therefore, there is a critical need in understanding the underlying cellular and molecular mechanisms regulating aging that will allow us to modify the aging process for healthy aging and alleviate age-related disease. Here, we reviewed the recent breakthroughs in the mechanistic understanding of biological aging, focusing on the adenosine monophosphate-activated kinase (AMPK), Sirtuin 1 (SIRT1) and mammalian target of rapamycin (mTOR) pathways, which are currently considered critical for aging. We also discussed how these proteins and pathways may potentially interact with each other to regulate aging. We further described how the knowledge of these pathways may lead to new interventions for antiaging and against age-related disease.

Original languageEnglish
Article number660
Pages (from-to)1-26
Number of pages26
Issue number3
StatePublished - Mar 2021


  • AMPK
  • Aging
  • Health span
  • Intervention
  • MTOR
  • SIRT1
  • Senescence
  • Signaling


Dive into the research topics of 'Key signaling pathways in aging and potential interventions for healthy aging'. Together they form a unique fingerprint.

Cite this