Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: A report from the Children's Oncology Group

Keyphrases

• High Risk 100%
• Childhood Acute Lymphoblastic Leukemia 100%
• Children's Oncology Group 100%
• Gene Expression Profile 100%
• B Cell Development 100%
• Precursor B-cell Acute Lymphoblastic Leukemia 66%
• Somatic Alterations 66%
• Pathway mutation 66%
• Signaling Pathway 33%
• Leukemia 33%
• Tumor Protein p53 (TP53) 33%
• CREB1 33%
• MUC4 33%
• Copy number Variation 33%
• Major Pathway 33%
• ETV6 33%
• Patient Selection 33%
• JAK Kinases 33%
• New Drug Targets 33%
• Ras Signaling 33%
• Tumor Suppressor Activity 33%
• Janus Kinase 33%
• Pediatric Cancer 33%
• RB Tumor Suppressor 33%
• Sequencing Effort 33%
• ADARB2 33%
• Recurrent mutation 33%
• Genetic Subtypes 33%
• TBL1XR1 33%
• Cancer Genome Sequencing 33%
• Multifocal ERG 33%
• ASMTL-AS1 33%
• RAS Pathway 33%
• Sequence mutation 33%

Biochemistry, Genetics and Molecular Biology

• Gene Expression 100%
• B Cell 100%
• Cell Maturation 100%
• Signal Transduction 66%
• Precursor 66%
• Kinase 33%
• Phosphotransferase 33%
• Candidate Gene 33%
• Genetics 33%
• Tumor Suppressor Protein 33%
• MUC4 33%
• ETV6 33%
• Janus Kinase 1 33%
• Cancer Genome Sequencing 33%