Ketone reductase activity and reduced haloperidol/haloperidol ratios in haloperidol-treated schizophrenic patients

Huang Fuh Huang, Michael W. Jann, Yung Te Tseng, Ming Cheng Chung, Ching Piao Chien, Wen Ho Chang

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Twenty schizophrenic patients were treated with a fixed haloperidol (HL) dose of 20 mg/day for 4 weeks. The conversion of HL to its reduced metabolite (reduced haloperidol, RH) occurs via the ketone reductase enzyme. RH is also converted back to HL by the cytochrome P450 2D6 isozyme. Ketone reductase activity can be measured in red blood cells. Plasma HL and RH levels were assayed by high performance liquid chromatography. Blood samples were obtained at baseline and during weeks 2 and 4 of HL therapy. Seventeen of 20 patients had ketone reductase values < 3. A significant correlation between ketone reductase activity and RH/HL plasma ratios was observed at week 4 in these 17 patients. Patients with ketone reductase activity |>3 could represent a subgroup of patients that metabolize HL differently. The wide interpatient variability observed with HL and RH plasma levels in HL-treated patients could reflect differences in ketone reductase activity and the metabolic status of debrisoquin hydroxylase (cytochrome P450IID6) in psychiatric patients.

Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalPsychiatry Research
Volume57
Issue number2
DOIs
StatePublished - 28 Jul 1995

Keywords

  • Debrisoquin hydroxylase
  • Neuroleptic treatment
  • Pharmacokinetics
  • Red blood cells

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