Involvement of protein kinase C-δ in DNA damage-induced apoptosis

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

Apoptosis is a highly orchestrated cell suicidal program required to maintain a balance between cell proliferation and cell death. A defect in apoptotic machinery can cause cancer. Many anticancer drugs are known to kill tumor cells by inducing apoptosis, and a defect in apoptosis can lead to anticancer drug resistance. Apoptosis is regulated by a complex cellular signaling network. Several members of the protein kinase C (PKC) family serve as substrates for caspases and PKCδ isozyme has been intimately associated with DNA damage-induced apoptosis. It can act both upstream and downstream of caspases. In response to apoptotic stimuli, the full-length and the catalytic fragment of PKCδ may translocate to distinct cellular compartments, including mitochondria and the nucleus, to reach their targets. Both activation and intracellular distribution of PKCδ may have significant impact on apoptosis. This review intends to assimilate recent views regarding the involvement of PKCδ in DNA damage-induced apoptosis.

Original languageEnglish
Pages (from-to)341-350
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume7
Issue number4
DOIs
StatePublished - 1 Jan 2003

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Protein Kinase C
DNA Damage
Apoptosis
Caspases
Drug Resistance
Isoenzymes
Neoplasms
Mitochondria
Cell Death
Cell Proliferation
Pharmaceutical Preparations

Keywords

  • Apoptosis
  • Caspases
  • Cytochrome c
  • DNA damage
  • Mitochondria
  • Protein kinase C

Cite this

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title = "Involvement of protein kinase C-δ in DNA damage-induced apoptosis",
abstract = "Apoptosis is a highly orchestrated cell suicidal program required to maintain a balance between cell proliferation and cell death. A defect in apoptotic machinery can cause cancer. Many anticancer drugs are known to kill tumor cells by inducing apoptosis, and a defect in apoptosis can lead to anticancer drug resistance. Apoptosis is regulated by a complex cellular signaling network. Several members of the protein kinase C (PKC) family serve as substrates for caspases and PKCδ isozyme has been intimately associated with DNA damage-induced apoptosis. It can act both upstream and downstream of caspases. In response to apoptotic stimuli, the full-length and the catalytic fragment of PKCδ may translocate to distinct cellular compartments, including mitochondria and the nucleus, to reach their targets. Both activation and intracellular distribution of PKCδ may have significant impact on apoptosis. This review intends to assimilate recent views regarding the involvement of PKCδ in DNA damage-induced apoptosis.",
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Involvement of protein kinase C-δ in DNA damage-induced apoptosis. / Basu, Alakananda.

In: Journal of Cellular and Molecular Medicine, Vol. 7, No. 4, 01.01.2003, p. 341-350.

Research output: Contribution to journalReview article

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AU - Basu, Alakananda

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AB - Apoptosis is a highly orchestrated cell suicidal program required to maintain a balance between cell proliferation and cell death. A defect in apoptotic machinery can cause cancer. Many anticancer drugs are known to kill tumor cells by inducing apoptosis, and a defect in apoptosis can lead to anticancer drug resistance. Apoptosis is regulated by a complex cellular signaling network. Several members of the protein kinase C (PKC) family serve as substrates for caspases and PKCδ isozyme has been intimately associated with DNA damage-induced apoptosis. It can act both upstream and downstream of caspases. In response to apoptotic stimuli, the full-length and the catalytic fragment of PKCδ may translocate to distinct cellular compartments, including mitochondria and the nucleus, to reach their targets. Both activation and intracellular distribution of PKCδ may have significant impact on apoptosis. This review intends to assimilate recent views regarding the involvement of PKCδ in DNA damage-induced apoptosis.

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