Involvement of Nrf2 in ocular diseases

Shehzad Batliwala, Christy Xavier, Yang Liu, Hongli Wu, Iok Hou Pang

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system - the Keap1-Nrf2-ARE pathway - on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

Original languageEnglish
Article number1703810
JournalOxidative Medicine and Cellular Longevity
Volume2017
DOIs
StatePublished - 2017

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