Involvement of Nrf2 in ocular diseases

Shehzad Batliwala, Christy Xavier, Yang Liu, Hongli Wu, Iok Hou Pang

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system - the Keap1-Nrf2-ARE pathway - on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

Original languageEnglish
Article number1703810
JournalOxidative Medicine and Cellular Longevity
StatePublished - 2017


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