TY - JOUR
T1 - Involvement of Nrf2 in ocular diseases
AU - Batliwala, Shehzad
AU - Xavier, Christy
AU - Liu, Yang
AU - Wu, Hongli
AU - Pang, Iok Hou
N1 - Funding Information:
This research is supported by the National Eye Institute (R21EY024635; Iok-Hou Pang) and by the Bright Focus Foundation for Macular Degeneration (M2015180; Hongli Wu).
Publisher Copyright:
© 2017 Shehzad Batliwala et al.
PY - 2017
Y1 - 2017
N2 - The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system - the Keap1-Nrf2-ARE pathway - on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.
AB - The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system - the Keap1-Nrf2-ARE pathway - on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.
UR - http://www.scopus.com/inward/record.url?scp=85018841500&partnerID=8YFLogxK
U2 - 10.1155/2017/1703810
DO - 10.1155/2017/1703810
M3 - Review article
C2 - 28473877
AN - SCOPUS:85018841500
SN - 1942-0900
VL - 2017
JO - Oxidative Medicine and Cellular Longevity
JF - Oxidative Medicine and Cellular Longevity
M1 - 1703810
ER -