Involvement of Nrf2 in ocular diseases

Shehzad Batliwala, Christy Xavier, Yang Liu, Hongli Wu, Iok Hou Pang

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

The human body harbors within it an intricate and delicate balance between oxidants and antioxidants. Any disruption in this checks-and-balances system can lead to harmful consequences in various organs and tissues, such as the eye. This review focuses on the effects of oxidative stress and the role of a particular antioxidant system - the Keap1-Nrf2-ARE pathway - on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. Together, they are the major causes of blindness in the world.

Original languageEnglish
Article number1703810
JournalOxidative Medicine and Cellular Longevity
Volume2017
DOIs
StatePublished - 1 Jan 2017

Fingerprint

Eye Diseases
Antioxidants
Oxidative stress
Macular Degeneration
Diabetic Retinopathy
Blindness
Ports and harbors
Human Body
Oxidants
Glaucoma
Cataract
Oxidative Stress
Tissue

Cite this

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Involvement of Nrf2 in ocular diseases. / Batliwala, Shehzad; Xavier, Christy; Liu, Yang; Wu, Hongli; Pang, Iok Hou.

In: Oxidative Medicine and Cellular Longevity, Vol. 2017, 1703810, 01.01.2017.

Research output: Contribution to journalReview article

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AU - Xavier, Christy

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AU - Wu, Hongli

AU - Pang, Iok Hou

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