Involvement of locus coeruleus and dorsal raphe nucleus in the reduction of intragastric pressure induced by ACR stimulation

Rong Ma, G. Y. Xu

Research output: Contribution to journalArticle

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Abstract

The effect of electrical stimulation of hypothalamic arcuate nucleus (ARC) on intragastric pressure (IGP) was observed on 80 Wistar rats anaesthetized with urethan. The main results are as follows: (1) Electrical stimulation of ARC could cause an obvious decrease of IGP. (2) The reduction of IGP induced by electrical stimulation of ARC was not affected by intracerebroventricular injection of naloxone. (3) After lesioning of locus coeruleus or dorsal raphe, the effect of ARC stimulation was depressed. The results suggest that the locus coeruleus and dorsal raphe nucleus may be involved in the reduction of IGP induced by ARC stimulation, but without the involvement of beta-endorphinergic neurons.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalSheng li xue bao : [Acta physiologica Sinica]
Volume43
Issue number5
StatePublished - 1 Jan 1991

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