Abstract
Mechanisms for loss and gain of introns are elusive. Reported here is a new pattern of intron loss which features a random loss of a single intron in a multiple-intron gene with its neighboring introns remained, which process is defined as intron exclusion. Intron exclusion is reminiscent of removal of a limited stretch of non-homologous sequence in a homologous recombination (HR) triggered by a double strand break (DSB), and therefore lends further evidence for a theory of intron loss through HR between a cDNA and its genomic intron-containing locus. Thus, a model for intron loss is formulated.
Original language | English |
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Pages (from-to) | 6361-6365 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 580 |
Issue number | 27 |
DOIs | |
State | Published - 27 Nov 2006 |
Keywords
- Alcohol dehydrogenase
- Double strand break
- Genome streamlining
- Homologous recombination
- Intron exclusion
- Intron loss