Intron exclusion and the mystery of intron loss

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Mechanisms for loss and gain of introns are elusive. Reported here is a new pattern of intron loss which features a random loss of a single intron in a multiple-intron gene with its neighboring introns remained, which process is defined as intron exclusion. Intron exclusion is reminiscent of removal of a limited stretch of non-homologous sequence in a homologous recombination (HR) triggered by a double strand break (DSB), and therefore lends further evidence for a theory of intron loss through HR between a cDNA and its genomic intron-containing locus. Thus, a model for intron loss is formulated.

Original languageEnglish
Pages (from-to)6361-6365
Number of pages5
JournalFEBS Letters
Issue number27
StatePublished - 27 Nov 2006


  • Alcohol dehydrogenase
  • Double strand break
  • Genome streamlining
  • Homologous recombination
  • Intron exclusion
  • Intron loss


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