Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits

Steven Idell, Ali Azghani, Shande Chen, Kathy Koenig, Andrew Mazar, Lalitha Kodandapani, Khalil Bdeir, Douglas Cines, Irina Kulikovskaya, Timothy Allen

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16 Scopus citations

Abstract

The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA and tPA reversed loculations at 96 hours after injury P ≤ .001, whereas low-molecular-weight urokinase and the scuPA mutant were ineffective. scuPA and tPA generated inhibitor complexes, induced fibrinolytic activity, and quenched plasminogen activator-1 activity in pleural fluids. The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective.

Original languageEnglish
Pages (from-to)419-440
Number of pages22
JournalExperimental Lung Research
Volume33
Issue number8-9
DOIs
StatePublished - 1 Oct 2007

Keywords

  • Fibrinolysis
  • Loculation
  • Pleurodesis
  • Tissue plasminogen activator
  • Urokinase

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