TY - JOUR
T1 - Intrapleural low-molecular-weight urokinase or tissue plasminogen activator versus single-chain urokinase in tetracycline-induced pleural loculation in rabbits
AU - Idell, Steven
AU - Azghani, Ali
AU - Chen, Shande
AU - Koenig, Kathy
AU - Mazar, Andrew
AU - Kodandapani, Lalitha
AU - Bdeir, Khalil
AU - Cines, Douglas
AU - Kulikovskaya, Irina
AU - Allen, Timothy
N1 - Funding Information:
Received 26 July 2007; accepted 31 August 2007. These studies were supported by NIH P01 HL076406-02 (SI, SS, DC). Address correspondence to Steven Idell, MD, PhD, Vice President for Research, Lab C-6, The University of Texas Health Science Center at Tyler, 11937 U.S. HWY 271, Tyler, TX 75708, USA.
PY - 2007/10
Y1 - 2007/10
N2 - The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA and tPA reversed loculations at 96 hours after injury P ≤ .001, whereas low-molecular-weight urokinase and the scuPA mutant were ineffective. scuPA and tPA generated inhibitor complexes, induced fibrinolytic activity, and quenched plasminogen activator-1 activity in pleural fluids. The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective.
AB - The authors compared the ability of a single dose of the proenzyme single-chain urokinase (scuPA), low-molecular-weight urokinase, tissue plasminogen activator (tPA), or a mutant site-inactive scuPA to resolve intrapleural loculations at 72 to 96 hours after tetracycline-induced pleural injury in rabbits. Both scuPA and tPA reversed loculations at 96 hours after injury P ≤ .001, whereas low-molecular-weight urokinase and the scuPA mutant were ineffective. scuPA and tPA generated inhibitor complexes, induced fibrinolytic activity, and quenched plasminogen activator-1 activity in pleural fluids. The authors conclude that scuPA reverses loculations as effectively as tPA at clinically applied intrapleural doses, whereas low-molecular-weight urokinase was ineffective.
KW - Fibrinolysis
KW - Loculation
KW - Pleurodesis
KW - Tissue plasminogen activator
KW - Urokinase
UR - http://www.scopus.com/inward/record.url?scp=36248952138&partnerID=8YFLogxK
U2 - 10.1080/01902140701703333
DO - 10.1080/01902140701703333
M3 - Article
C2 - 17994370
AN - SCOPUS:36248952138
SN - 0190-2148
VL - 33
SP - 419
EP - 440
JO - Experimental Lung Research
JF - Experimental Lung Research
IS - 8-9
ER -