Intracranial atherosclerotic disease

Yuan Wang; Ran Meng; Gang Liu; Catherine Cao; Fenghua Chen; Kunlin Jin; Xunming Ji; Guodong Cao

doi:10.1016/j.nbd.2018.11.008

Intracranial atherosclerotic disease

Yuan Wang, Ran Meng, Gang Liu, Catherine Cao, Fenghua Chen, Kunlin Jin, Xunming Ji, Guodong Cao

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.

Original language	English
Pages (from-to)	118-132
Number of pages	15
Journal	Neurobiology of Disease
Volume	124
DOIs	https://doi.org/10.1016/j.nbd.2018.11.008
State	Published - Apr 2019

Keywords

Angiography
Biomarker
Diagnosis
Intracranial atherosclerosis
Ischemic conditioning
Treatment

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10.1016/j.nbd.2018.11.008

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title = "Intracranial atherosclerotic disease",

abstract = "Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.",

keywords = "Angiography, Biomarker, Diagnosis, Intracranial atherosclerosis, Ischemic conditioning, Treatment",

author = "Yuan Wang and Ran Meng and Gang Liu and Catherine Cao and Fenghua Chen and Kunlin Jin and Xunming Ji and Guodong Cao",

note = "Funding Information: This study was sponsored by the 12th Five-Year Plan for Energy, Science and Technology support program 2013BAI07B01 (to X.J.) and the Chinese National Natural Science Foundation 81371289 (to X.J.), and by National Institutes of Health/NINDS grants NS079345 (to G.C.) and the Department of Veterans Affairs Merit Review grants BX002346 and BX003923 (to G.C.). Publisher Copyright: {\textcopyright} 2018",

year = "2019",

month = apr,

doi = "10.1016/j.nbd.2018.11.008",

language = "English",

volume = "124",

pages = "118--132",

journal = "Neurobiology of Disease",

issn = "0969-9961",

publisher = "Academic Press Inc.",

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TY - JOUR

T1 - Intracranial atherosclerotic disease

AU - Wang, Yuan

AU - Meng, Ran

AU - Liu, Gang

AU - Cao, Catherine

AU - Chen, Fenghua

AU - Jin, Kunlin

AU - Ji, Xunming

AU - Cao, Guodong

N1 - Funding Information: This study was sponsored by the 12th Five-Year Plan for Energy, Science and Technology support program 2013BAI07B01 (to X.J.) and the Chinese National Natural Science Foundation 81371289 (to X.J.), and by National Institutes of Health/NINDS grants NS079345 (to G.C.) and the Department of Veterans Affairs Merit Review grants BX002346 and BX003923 (to G.C.). Publisher Copyright: © 2018

PY - 2019/4

Y1 - 2019/4

N2 - Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.

AB - Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.

KW - Angiography

KW - Biomarker

KW - Diagnosis

KW - Intracranial atherosclerosis

KW - Ischemic conditioning

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=85056771243&partnerID=8YFLogxK

U2 - 10.1016/j.nbd.2018.11.008

DO - 10.1016/j.nbd.2018.11.008

M3 - Article

C2 - 30439443

AN - SCOPUS:85056771243

SN - 0969-9961

VL - 124

SP - 118

EP - 132

JO - Neurobiology of Disease

JF - Neurobiology of Disease

ER -

Intracranial atherosclerotic disease

Abstract

Keywords

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