Intracranial atherosclerotic disease

Yuan Wang, Ran Meng, Gang Liu, Catherine Cao, Fenghua Chen, Kunlin Jin, Xunming Ji, Guodong Cao

Research output: Contribution to journalArticle

Abstract

Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.

Original languageEnglish
Pages (from-to)118-132
Number of pages15
JournalNeurobiology of Disease
Volume124
DOIs
StatePublished - Apr 2019

Fingerprint

Intracranial Arteriosclerosis
Stroke
Therapeutics
Recurrence
Risk Management
Pathologic Processes
Hypothermia
Angiography
Pathologic Constriction
Epidemiology
Biomarkers

Keywords

  • Angiography
  • Biomarker
  • Diagnosis
  • Intracranial atherosclerosis
  • Ischemic conditioning
  • Treatment

Cite this

Wang, Y., Meng, R., Liu, G., Cao, C., Chen, F., Jin, K., ... Cao, G. (2019). Intracranial atherosclerotic disease. Neurobiology of Disease, 124, 118-132. https://doi.org/10.1016/j.nbd.2018.11.008
Wang, Yuan ; Meng, Ran ; Liu, Gang ; Cao, Catherine ; Chen, Fenghua ; Jin, Kunlin ; Ji, Xunming ; Cao, Guodong. / Intracranial atherosclerotic disease. In: Neurobiology of Disease. 2019 ; Vol. 124. pp. 118-132.
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Wang, Y, Meng, R, Liu, G, Cao, C, Chen, F, Jin, K, Ji, X & Cao, G 2019, 'Intracranial atherosclerotic disease', Neurobiology of Disease, vol. 124, pp. 118-132. https://doi.org/10.1016/j.nbd.2018.11.008

Intracranial atherosclerotic disease. / Wang, Yuan; Meng, Ran; Liu, Gang; Cao, Catherine; Chen, Fenghua; Jin, Kunlin; Ji, Xunming; Cao, Guodong.

In: Neurobiology of Disease, Vol. 124, 04.2019, p. 118-132.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Intracranial atherosclerotic disease

AU - Wang, Yuan

AU - Meng, Ran

AU - Liu, Gang

AU - Cao, Catherine

AU - Chen, Fenghua

AU - Jin, Kunlin

AU - Ji, Xunming

AU - Cao, Guodong

PY - 2019/4

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AB - Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.

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