Intracranial atherosclerotic disease

Yuan Wang, Ran Meng, Gang Liu, Catherine Cao, Fenghua Chen, Kunlin Jin, Xunming Ji, Guodong Cao

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Intracranial atherosclerosis (ICAS) is a progressive pathological process that causes progressive stenosis and cerebral hypoperfusion and is a major cause of stroke occurrence and recurrence around the world. Multiple factors contribute to the development of ICAS. Angiography imaging techniques can improve the diagnosis of and the selection of appropriate treatment regimens for ICAS. Neither aggressive medication nor endovascular interventions can eradicate stroke recurrence in patients with ICAS. Non-pharmacological therapies such as remote ischemic conditioning and hypothermia are emerging. Comprehensive therapy with medication in combination with endovascular intervention and/or non-pharmacological treatment may be a potential strategy for ICAS treatment in the future. We summarized the epidemiology, pathophysiological mechanisms, risk factors, biomarkers, imaging and management of ICAS.

Original languageEnglish
Pages (from-to)118-132
Number of pages15
JournalNeurobiology of Disease
StatePublished - Apr 2019


  • Angiography
  • Biomarker
  • Diagnosis
  • Intracranial atherosclerosis
  • Ischemic conditioning
  • Treatment


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