Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study

Hong Wang, Xiangrong Shi, Hannah Schenck, James R. Hall, Sarah E. Ross, Geoffrey P. Kline, Shande Chen, Robert T. Mallet, Peijie Chen

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT's safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O2 and room-air, each 5 minutes, for 8 cycles/session, 3 sessions/wk for 8 weeks. The patients' resting arterial pressures fell by 5 to 7 mm Hg (P < .05) and cerebral tissue oxygenation increased (P < .05) following IHT. Intermittent hypoxia training enhanced hypoxemia-induced cerebral vasodilation (P < .05) and improved mini-mental state examination and digit span scores from 25.7 ± 0.4 to 27.7 ± 0.6 (P = .038) and from 24.7 ± 1.2 to 26.1 ± 1.3 (P = .047), respectively. California verbal learning test score tended to increase (P = .102), but trail making test-B and controlled oral word association test scores were unchanged. Adaptation to moderate IHT may enhance cerebral oxygenation and hypoxia-induced cerebrovasodilation while improving short-term memory and attention in elderly patients with aMCI.

Original languageEnglish
Pages (from-to)1533317519896725
JournalAmerican journal of Alzheimer's disease and other dementias
Volume35
DOIs
StatePublished - 1 Jan 2020

Keywords

  • cerebral tissue O2 saturation
  • cerebrovascular response
  • cognitive function
  • elderly
  • hypoxemia

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