@article{22cea252d09d4833be6b7d6464985968,
title = "Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study",
abstract = "Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT{\textquoteright}s safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O2 and room-air, each 5 minutes, for 8 cycles/session, 3 sessions/wk for 8 weeks. The patients{\textquoteright} resting arterial pressures fell by 5 to 7 mm Hg (P <.05) and cerebral tissue oxygenation increased (P <.05) following IHT. Intermittent hypoxia training enhanced hypoxemia-induced cerebral vasodilation (P <.05) and improved mini-mental state examination and digit span scores from 25.7 ± 0.4 to 27.7 ± 0.6 (P =.038) and from 24.7 ± 1.2 to 26.1 ± 1.3 (P =.047), respectively. California verbal learning test score tended to increase (P =.102), but trail making test-B and controlled oral word association test scores were unchanged. Adaptation to moderate IHT may enhance cerebral oxygenation and hypoxia-induced cerebrovasodilation while improving short-term memory and attention in elderly patients with aMCI.",
keywords = "cerebral tissue O saturation, cerebrovascular response, cognitive function, elderly, hypoxemia",
author = "Hong Wang and Xiangrong Shi and Hannah Schenck and Hall, {James R.} and Ross, {Sarah E.} and Kline, {Geoffrey P.} and Shande Chen and Mallet, {Robert T.} and Peijie Chen",
note = "Funding Information: We thank all participants for their cheerful cooperation during this clinical study. Drs Sid O{\textquoteright}Bryant and Meharvan Singh, Departments of Pharmacology and Neuroscience, University of North Texas Health Science Center; Benjamin Williams, Departments of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center; and Roderick McColl, Department of Radiology, University of Texas Southwestern Medical Center, provided incisive advice during the development of this study. Study data are available from the corresponding author on request. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a Texas Alzheimer{\textquoteright}s Research & Care Consortium—Investigator Grant Program award to XR from the Texas Council on Alzheimer{\textquoteright}s Disease and Related Disorders, and an intramural research award to RTM from UNTHSC{\textquoteright}s Division of Research Development and Commercialization. Funding Information: The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by a Texas Alzheimer{\textquoteright}s Research & Care Consortium—Investigator Grant Program award to XR from the Texas Council on Alzheimer{\textquoteright}s Disease and Related Disorders, and an intramural research award to RTM from UNTHSC{\textquoteright}s Division of Research Development and Commercialization. Publisher Copyright: {\textcopyright} The Author(s) 2020.",
year = "2020",
doi = "10.1177/1533317519896725",
language = "English",
volume = "35",
journal = "American journal of Alzheimer's disease and other dementias",
issn = "1938-2731",
publisher = "SAGE Publications Inc.",
}