Interactions of the hexobarbital enantiomers with rat liver microsomes

Dennis R. Feller, William Charles Lubawy

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

There is a stcreoselective difference in the interaction of the hexobarbital enantiomers with rat liver microsomes. The metabolism of the hexobarbital isomers was elevated in microsomes isolated from rats prctreated with phenobarbital and the (+)-isomer metabolized to a greater degree in control and phenobarbital-induced preparations. (+)-Hexobarbital was observed to be more effective than the (−)-isomer in the stimulation of endogenous NADPH oxidation and inhibition of ethylmorphine N-demethylation. In binding spectral experiments, the (+)-isomer exhibited larger Amax (maximum absorbance) values and slightly lower apparent Ks (spectral dissociation) constants than the (−)-form in control and phenobarbital-induced microsomal preparations.

Original languageEnglish
Pages (from-to)129-137
Number of pages9
JournalPharmacology
Volume9
Issue number3
DOIs
StatePublished - 1 Jan 1973

Keywords

  • Binding spectra
  • Enantiomers
  • Hexobarbital
  • Interaction
  • Metabolism

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