Interactions between vascular endothelial growth factor and neuroglobin

Kunlin Jin, Xiao Mao, Lin Xie, David A. Greenberg

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown. To address this issue, we measured Ngb levels in VEGF-treated mouse cerebrocortical cultures and VEGF levels in cerebrocortical cultures from Ngb-overexpressing transgenic mice. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. These findings provide further insight into hypoxia-stimulated neuronal signaling pathways.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalNeuroscience letters
Issue number1
StatePublished - 21 Jun 2012


  • Hypoxia
  • Neuroglobin
  • Vascular endothelial growth factor


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