Interactions between vascular endothelial growth factor and neuroglobin

Kunlin Jin, Xiao Mao, Lin Xie, David A. Greenberg

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown. To address this issue, we measured Ngb levels in VEGF-treated mouse cerebrocortical cultures and VEGF levels in cerebrocortical cultures from Ngb-overexpressing transgenic mice. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. These findings provide further insight into hypoxia-stimulated neuronal signaling pathways.

Original languageEnglish
Pages (from-to)47-50
Number of pages4
JournalNeuroscience Letters
Volume519
Issue number1
DOIs
StatePublished - 21 Jun 2012

Keywords

  • Hypoxia
  • Neuroglobin
  • Vascular endothelial growth factor

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