Interaction of bone marrow stem cells with other cells

Hongxia Zhang, Shengwei Huang, Jiangnan Hu, Brian Wang, Kunlin Jin

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Transplantation of bone marrow stem cells (BMSCs) as a regenerative cell replacement therapy for stroke holds great promise. However, the mechanisms underlying functional recovery after stroke remain unclear. Clearly, BMSCs benefit the neurological dysfunction in either direct or indirect methods through the interaction with other cells. In this chapter, we review the direct and indirect interactions of transplanted BMSCs with HSCs, immune cells, neural stem cells (NSCs), neurons, astrocytes, and endothelial cells for better understanding of the mechanisms underlying BMSC-mediated neurological function improvement after stroke.

Original languageEnglish
Title of host publicationBone Marrow Stem Cell Therapy for Stroke
PublisherSpringer Singapore
Number of pages25
ISBN (Electronic)9789811029295
ISBN (Print)9789811029288
StatePublished - 1 Jan 2016


  • Bone marrow stem cells
  • Immune cells
  • Interaction
  • Transplantation


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