Interaction of astrocytes and T cells in physiological and pathological conditions

Luokun Xie, Shao Hua Yang

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The central nervous system (CNS) has long been recognized as a site of 'immune privilege' because of the existence of the blood brain barrier (BBB) which presumably isolates CNS from the peripheral immunosurveillance. Different from the peripheral organs, CNS is unique in response to all forms of CNS injury and disease which is mainly mediated by resident microglia and astrocyte. There is increasing evidence that immune cells are not only involved in neuroinflammation process but also the maintenance of CNS homeostasis. T cells, an important immune cell population, are involved in the pathogenesis of some neurological diseases by inducing either innate or adaptive immune responses. Astrocytes, which are the most abundant cell type in the CNS, maintain the integrity of BBB and actively participate in the initiation and progression of neurological diseases. Surprisingly, how astrocytes and T cells interact and the consequences of their interaction are not clear. In this review we briefly summarized T cells diversity and astrocyte function. Then, we examined the evidence for the astrocytes and T cells interaction under physiological and pathological conditions including ischemic stroke, multiple sclerosis, viral infection, and Alzheimer's disease. This article is part of a Special Issue entitled SI: Cell Interactions In Stroke.

Original languageEnglish
Pages (from-to)63-73
Number of pages11
JournalBrain Research
StatePublished - 14 Oct 2015


  • Alzheimer's disease
  • Astrocyte
  • Central nervous system
  • Multiple sclerosis
  • Stroke
  • T cells


Dive into the research topics of 'Interaction of astrocytes and T cells in physiological and pathological conditions'. Together they form a unique fingerprint.

Cite this