Interaction between actin and HMM

Julian Borjdo; Marco Giordano

doi:10.1016/S0006-291X(86)80207-8

Interaction between actin and HMM

Julian Borjdo, Marco Giordano

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

It is shown that the interaction between actin and HMM results in a rapid precipitaiton of acto-HMM gel upon addition of MgATP. This is a simple demonstration of the idea that the formation of myosin filaments is not essential for mechanochemical reaction (muscle contraction) to occur and that the soluble myosin heads are competent to interact with actin to produce mechanical effect Our findings also strongly support earlier suggestion that each head of one HMM molecule is able to bind to a different actin filament.

Original language	English
Pages (from-to)	541-546
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	141
Issue number	2
DOIs	https://doi.org/10.1016/S0006-291X(86)80207-8
State	Published - 15 Dec 1986

Access to Document

10.1016/S0006-291X(86)80207-8

Cite this

@article{294ee163c8194a92a3830910f27801ae,

title = "Interaction between actin and HMM",

abstract = "It is shown that the interaction between actin and HMM results in a rapid precipitaiton of acto-HMM gel upon addition of MgATP. This is a simple demonstration of the idea that the formation of myosin filaments is not essential for mechanochemical reaction (muscle contraction) to occur and that the soluble myosin heads are competent to interact with actin to produce mechanical effect Our findings also strongly support earlier suggestion that each head of one HMM molecule is able to bind to a different actin filament.",

author = "Julian Borjdo and Marco Giordano",

note = "Funding Information: ACKNOWLEDGEMENTS: We thank Profs. Manuel F. Morales and Leonard Pellet and Dr. Andrze~ Kasprzak for useful discussions and help. This work was supported by USPHS grant HL-16683 and by MDA basic research grant (to J.B.).",

year = "1986",

month = dec,

day = "15",

doi = "10.1016/S0006-291X(86)80207-8",

language = "English",

volume = "141",

pages = "541--546",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Interaction between actin and HMM

AU - Borjdo, Julian

AU - Giordano, Marco

N1 - Funding Information: ACKNOWLEDGEMENTS: We thank Profs. Manuel F. Morales and Leonard Pellet and Dr. Andrze~ Kasprzak for useful discussions and help. This work was supported by USPHS grant HL-16683 and by MDA basic research grant (to J.B.).

PY - 1986/12/15

Y1 - 1986/12/15

N2 - It is shown that the interaction between actin and HMM results in a rapid precipitaiton of acto-HMM gel upon addition of MgATP. This is a simple demonstration of the idea that the formation of myosin filaments is not essential for mechanochemical reaction (muscle contraction) to occur and that the soluble myosin heads are competent to interact with actin to produce mechanical effect Our findings also strongly support earlier suggestion that each head of one HMM molecule is able to bind to a different actin filament.

AB - It is shown that the interaction between actin and HMM results in a rapid precipitaiton of acto-HMM gel upon addition of MgATP. This is a simple demonstration of the idea that the formation of myosin filaments is not essential for mechanochemical reaction (muscle contraction) to occur and that the soluble myosin heads are competent to interact with actin to produce mechanical effect Our findings also strongly support earlier suggestion that each head of one HMM molecule is able to bind to a different actin filament.

UR - http://www.scopus.com/inward/record.url?scp=0022903470&partnerID=8YFLogxK

U2 - 10.1016/S0006-291X(86)80207-8

DO - 10.1016/S0006-291X(86)80207-8

M3 - Article

C2 - 3541936

AN - SCOPUS:0022903470

SN - 0006-291X

VL - 141

SP - 541

EP - 546

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Interaction between actin and HMM

Abstract

Access to Document

Other files and links

Fingerprint

Cite this