Interaction between actin and HMM

Julian Borjdo, Marco Giordano

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It is shown that the interaction between actin and HMM results in a rapid precipitaiton of acto-HMM gel upon addition of MgATP. This is a simple demonstration of the idea that the formation of myosin filaments is not essential for mechanochemical reaction (muscle contraction) to occur and that the soluble myosin heads are competent to interact with actin to produce mechanical effect Our findings also strongly support earlier suggestion that each head of one HMM molecule is able to bind to a different actin filament.

Original languageEnglish
Pages (from-to)541-546
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 15 Dec 1986


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