Integration of mass spectrometry into early-phase discovery and development of central nervous system agents

Keyphrases

• Mass Spectrometry 100%
• Central Nervous System Agents 100%
• Central Nervous System 33%
• Rodents 33%
• Neuropeptide FF 33%
• Detection Sensitivity 33%
• Thyrotropin 33%
• Brain Concentration 33%
• Electrospray Ionization Mass Spectrometry 33%
• Tissue Matrix 33%
• Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) 33%
• Microdialysis 33%
• Intravenous Administration 33%
• Extracellular Concentration 33%
• Transport Mechanism 33%
• New Agents 33%
• Immobilized Artificial Membrane Chromatography 33%
• Quadrupole Ion Trap 33%
• Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS) 33%
• Metabolic Activation 33%
• Increased Throughput 33%
• Atmospheric Pressure Ionization Mass Spectrometry 33%
• Peptide Derivatives 33%
• Mixture Characterization 33%
• Nanoelectrospray 33%
• Focused Library 33%

Chemistry

• Mass Spectrometry 100%
• Central Nervous System Agent 100%
• Electrospray Ionization 33%
• Tandem Mass Spectrometry 33%
• FT/ICR Mass Spectrometry 33%
• Protirelin Derivative 33%
• Microdialysis 33%
• Liquid Chromatography Tandem Mass Spectrometry 33%
• Membrane Chromatography 33%
• Quadrupole 33%
• Ion Trap 33%
• Neuropeptide FF 33%
• Atmospheric Pressure Ionization Mass Spectrometry 33%
• Metabolic Activation 33%
• Lead Compound 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Central Nervous System Agent 100%
• Neuropeptide FF 33%
• Electrospray Ionization 33%
• Lead Compound 33%
• Protirelin Derivative 33%
• Microdialysis 33%
• Ion Cyclotron Resonance 33%
• Peptide Derivative 33%