Insights on Foxn1 biological significance and usages of the "nude" mouse in studies of T-Lymphopoiesis

Zhijie Zhang, Preston Burnley, Brandon Coder, Dong Ming Su

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Mutation in the "nude" gene, i.e. the FoxN1 gene, induces a hairless phenotype and a rudi-mentary thymus gland in mice (nude mouse) and humans (T-cell related primary immuno-deficiency). Conventional FoxN1 gene knockout and transgenic mouse models have been generated for studies of FoxN1 gene function related to skin and immune diseases, and for cancer models. It appeared that FoxN1's role was fully understood and the nude mouse model was fully utilized. However, in recent years, with the development of inducible gene knockout/knockin mouse models with the loxP-Cre(ER T) and diphtheria toxin recep-tor-induced cell abolished systems, it appears that the complete repertoire of FoxN1's roles and deep-going usage of nude mouse model in immune function studies have just begun. Here we summarize the research progress made by several recent works studying the role of FoxN1 in the thymus and utilizing nude and "second (conditional) nude" mouse models for studies of T-cell development and function. We also raise questions and propose further consideration of FoxN1 functions and utilizing this mouse model for immune function studies.

Original languageEnglish
Pages (from-to)1156-1167
Number of pages12
JournalInternational journal of biological sciences
Issue number8
StatePublished - 24 Sep 2012


  • FoxN1 gene
  • T-Lymphopoiesis


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