Abstract
Objective: To analyze allelic association with clinical outcome in a cohort of burn patients. Patients: Two hundred twenty-eight individuals with burns ≥15% total body surface area without significant non-burn related trauma who survived >48 hours post-admission were enrolled. One hundred fifty-nine of these patients were analyzed previously. Methods: Candidate polymorphisms within interleukin-1 beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), cellular differentiation marker 14 (CD14) and toll-like receptor 4 (TLR4) were evaluated by logistic regression analysis for association with increased risk for severe sepsis (sepsis plus organ dysfunction or shock). Results: After adjustment for age, burn size, ethnicity, gender and inhalation injury, alleles at TNF-α (308G, p=0.013), TLR4 (+896G, p=0.027), IL-6 (174C, p=0.040) and CD14 (159C, p=0.047) were significantly associated with an increased risk for severe sepsis. Conclusions: Carriage of variant alleles at immune response genes were associated with increased risk for severe sepsis after burn injury.
Original language | English |
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Pages (from-to) | 250-255 |
Number of pages | 6 |
Journal | Clinical Medicine and Research |
Volume | 4 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2006 |
Keywords
- Allelic association
- Burns
- CD14
- IL-6
- Polymorphism
- SNP
- Sepsis
- TLR4
- TNF-α