Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy

Keyphrases

• Murine Model 100%
• Innate Immune Response 100%
• Globoid Cell Leukodystrophy 100%
• TLR2 80%
• Cell Death 60%
• Oligodendrocyte 60%
• Oligodendrocyte Cells 60%
• Reporter Cells 40%
• Galactocerebrosidase 40%
• Psychosine 40%
• Microglia/macrophages 40%
• Apoptosis 20%
• Toll-like 20%
• Central Nervous System 20%
• Morphological Changes 20%
• Astrocyte Activation 20%
• Chemokines 20%
• Hindbrain 20%
• Astroglial Activation 20%
• Cerebellum 20%
• Activated Microglia 20%
• Astroglial Proliferation 20%
• Receptor 2 20%
• Pathological Changes 20%
• Demyelination 20%
• Cell Cytokines 20%
• Inflammatory Events 20%
• Glial Cell Activation 20%
• TLR2 Ligands 20%
• Lysosomal Storage Disease 20%
• Cytokines/chemokines 20%
• Macrophage Recruitment 20%
• Potential Drivers 20%

Neuroscience

• Oligodendrocyte 100%
• Leukodystrophy 100%
• TLR 2 100%
• Cell Death 50%
• Macrophage 50%
• Microglia 33%
• Chemokine 33%
• Psychosine 33%
• Galactosylceramidase 33%
• Cytokine 33%
• In Vitro 16%
• Central Nervous System 16%
• Astrocyte 16%
• Glial Cells 16%
• Hindbrain 16%
• Cerebellum 16%
• Cell Activation 16%
• Programmed Cell Death 16%