Inline flow sensor for ventriculoperitoneal shunts: Experimental evaluation in swine

Chuchu Qin, Albert H. Olivencia-Yurvati, Arthur G. Williams, Dane Eskildsen, Robert T. Mallet, Purnendu K. Dasgupta

Research output: Contribution to journalArticle

Abstract

Shunts are commonly employed to treat hydrocephalus, a severe central nervous disease caused by the buildup of cerebrospinal fluid in the brain. These shunts divert excessive cerebrospinal fluid from brain ventricles to other body cavities, thereby relieving the symptoms. However, these shunts are highly prone to failure due to obstruction from cellular debris, leading to cerebrospinal fluid accumulation in the brain and exacerbation of neurological symptoms. Therefore, there is a clinical need for a reliable, non-invasive method of monitoring shunt performance. Recently, a simple inline flow sensor was reported for monitoring ventriculoperitoneal shunting of cerebrospinal fluid in hydrocephalus treatment. The present work aimed to evaluate performance of the device in an animal model of hydrocephalus. Sensor-equipped shunt tubes were placed in anesthetized, juvenile swine. The flows reported by the sensor were compared with gravimetric flow measurements. Robust correlations (r ≈ 0.87–0.96)between the gravimetric and sensor-reported flows were obtained in 4 of the 6 experiments. The mean slope of the linear relationship of the gravimetrically determined vs. sensor flow rates was 0.98 ± 0.09 in the 6 experiments, indicating the sensor accurately reported shunt flows up to 35 ml/h. The sensor responded immediately to abrupt flow changes following cerebroventricular fluid injections. Minor hardware problems were identified and corrected. These experiments provide practical guidance for future preclinical testing of the device.

Original languageEnglish
Pages (from-to)66-72
Number of pages7
JournalMedical Engineering and Physics
Volume67
DOIs
StatePublished - May 2019

Fingerprint

Ventriculoperitoneal Shunt
Cerebrospinal Fluid
Swine
Hydrocephalus
Cerebrospinal fluid
Sensors
Brain
Equipment and Supplies
Animal Models
Monitoring
Experiments
Injections
Flow measurement
Debris
Animals
Flow rate
Hardware
Fluids
Testing
Therapeutics

Keywords

  • Bidirectional thermal transducer
  • Flow sensor
  • Hydrocephalus
  • Ventriculoperitoneal shunt

Cite this

Qin, Chuchu ; Olivencia-Yurvati, Albert H. ; Williams, Arthur G. ; Eskildsen, Dane ; Mallet, Robert T. ; Dasgupta, Purnendu K. / Inline flow sensor for ventriculoperitoneal shunts : Experimental evaluation in swine. In: Medical Engineering and Physics. 2019 ; Vol. 67. pp. 66-72.
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Inline flow sensor for ventriculoperitoneal shunts : Experimental evaluation in swine. / Qin, Chuchu; Olivencia-Yurvati, Albert H.; Williams, Arthur G.; Eskildsen, Dane; Mallet, Robert T.; Dasgupta, Purnendu K.

In: Medical Engineering and Physics, Vol. 67, 05.2019, p. 66-72.

Research output: Contribution to journalArticle

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T2 - Experimental evaluation in swine

AU - Qin, Chuchu

AU - Olivencia-Yurvati, Albert H.

AU - Williams, Arthur G.

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