Inhibitory action of the defensive discharge of the grasshopper, poecilocerus pictus, on certain enzymes in the lizard, calotes nemoricola

Y. Sreenivasulu, Riyaz Mahammad Basha, G. Rajaramireddy

Research output: Contribution to journalArticle

Abstract

Administration of the defensive secretion of the grasshopper, Poecilocerus pictus inhibited acetyl-cholinesterase (AChE) and adenosine triphosphatases (ATPases) in the brain and muscle tissues of the garden lizard, Calotes nemoricola. The inhibition was gradual, continuous and irreversible with lethal doses of the defensive secretion, whereas the inhibition observed with sublethal doses was followed by an increase towards control levels within 24 h after injection. In vitro application of defensive secretion also showed concentration-dependent inhibition in the activity of AChE and ATPases in the tissue homogenates. Inhibition in AChE activity might be a factor for the observed mortality in the defensive fluid-treated lizards. Since the cardenolides are known to inhibit the activity of ATPases, the inhibition in the activity of ATPases observed in the present study suggests the presence of cardenolides in the defensive fluid of P. pictus.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume11
Issue number2
DOIs
StatePublished - 1 Dec 1996

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Grasshoppers
Lizards
Adenosine Triphosphatases
Cholinesterases
Cardenolides
Enzymes
Muscles
Injections
Mortality
Brain

Keywords

  • Grasshopper
  • acetylcholinesterase
  • adenosine triphosphatase
  • inhibition
  • lizard

Cite this

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title = "Inhibitory action of the defensive discharge of the grasshopper, poecilocerus pictus, on certain enzymes in the lizard, calotes nemoricola",
abstract = "Administration of the defensive secretion of the grasshopper, Poecilocerus pictus inhibited acetyl-cholinesterase (AChE) and adenosine triphosphatases (ATPases) in the brain and muscle tissues of the garden lizard, Calotes nemoricola. The inhibition was gradual, continuous and irreversible with lethal doses of the defensive secretion, whereas the inhibition observed with sublethal doses was followed by an increase towards control levels within 24 h after injection. In vitro application of defensive secretion also showed concentration-dependent inhibition in the activity of AChE and ATPases in the tissue homogenates. Inhibition in AChE activity might be a factor for the observed mortality in the defensive fluid-treated lizards. Since the cardenolides are known to inhibit the activity of ATPases, the inhibition in the activity of ATPases observed in the present study suggests the presence of cardenolides in the defensive fluid of P. pictus.",
keywords = "Grasshopper, acetylcholinesterase, adenosine triphosphatase, inhibition, lizard",
author = "Y. Sreenivasulu and Basha, {Riyaz Mahammad} and G. Rajaramireddy",
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T1 - Inhibitory action of the defensive discharge of the grasshopper, poecilocerus pictus, on certain enzymes in the lizard, calotes nemoricola

AU - Sreenivasulu, Y.

AU - Basha, Riyaz Mahammad

AU - Rajaramireddy, G.

PY - 1996/12/1

Y1 - 1996/12/1

N2 - Administration of the defensive secretion of the grasshopper, Poecilocerus pictus inhibited acetyl-cholinesterase (AChE) and adenosine triphosphatases (ATPases) in the brain and muscle tissues of the garden lizard, Calotes nemoricola. The inhibition was gradual, continuous and irreversible with lethal doses of the defensive secretion, whereas the inhibition observed with sublethal doses was followed by an increase towards control levels within 24 h after injection. In vitro application of defensive secretion also showed concentration-dependent inhibition in the activity of AChE and ATPases in the tissue homogenates. Inhibition in AChE activity might be a factor for the observed mortality in the defensive fluid-treated lizards. Since the cardenolides are known to inhibit the activity of ATPases, the inhibition in the activity of ATPases observed in the present study suggests the presence of cardenolides in the defensive fluid of P. pictus.

AB - Administration of the defensive secretion of the grasshopper, Poecilocerus pictus inhibited acetyl-cholinesterase (AChE) and adenosine triphosphatases (ATPases) in the brain and muscle tissues of the garden lizard, Calotes nemoricola. The inhibition was gradual, continuous and irreversible with lethal doses of the defensive secretion, whereas the inhibition observed with sublethal doses was followed by an increase towards control levels within 24 h after injection. In vitro application of defensive secretion also showed concentration-dependent inhibition in the activity of AChE and ATPases in the tissue homogenates. Inhibition in AChE activity might be a factor for the observed mortality in the defensive fluid-treated lizards. Since the cardenolides are known to inhibit the activity of ATPases, the inhibition in the activity of ATPases observed in the present study suggests the presence of cardenolides in the defensive fluid of P. pictus.

KW - Grasshopper

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