Inhibition of the hydro-osmotic response to vasopressin and hypertonicity by phenothiazines and W7, calmodulin antagonists

Thomas Yorio, Ron Royce, Janet Mattern, Larry X. Oakford, A. J. Mia, Nimman Tarapoom

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

1. 1. Phenothiazines and W7, calmodulin antagonists, inhibit the water flow response produced by ADH, exogenous cyclic AMP, phosphodiesterase inhibition and serosal hypertonicity. 2. 2. Calmodulin antagonists had no effect on osmotic water movement in the absence of hormone. 3. 3. Calmodulin was isolated and localized by immunofluorescence in bladder epithelial cells. Phenothiazines inhibited toad bladder calmodulin activation of phosphodiesterase and prevented fluorescent antibody recognition. 4. 4. The results suggest that the calcium-calmodulin process plays a role in the hydro-osmotic response to ADH and that produced by serosal hypertonicity. The calmodulin common site occurs subsequent to cyclic AMP formation, perhaps on the microtubule-microfilament system.

Original languageEnglish
Pages (from-to)347-353
Number of pages7
JournalGeneral Pharmacology
Volume16
Issue number4
DOIs
StatePublished - 1985

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