Inhibition of p-mTOR represses transcription of PS1 and Notch 1-signaling

Keyphrases

• Mammalian Target of Rapamycin (mTOR) 100%
• Phosphorylation 100%
• Presenilin 100%
• Notch1 Signaling 100%
• Rapamycin 71%
• Abeta 57%
• Mammalian Target of Rapamycin Signaling 42%
• Notch Intracellular Domain 42%
• Protein Level 28%
• Hes1 28%
• Alzheimer's Disease Model 28%
• P70S6K 14%
• Notch Signaling 14%
• Cognitive Deficits 14%
• Decreased Expression 14%
• Tau Pathology 14%
• Amyloid-β Protein Precursor (AβPP) 14%
• Notch1 14%
• 3xTg-AD 14%
• Notch Receptors 14%
• Cellular Homeostasis 14%
• Catalytic Subunit 14%
• γ-secretase 14%
• 4E-BP1 14%
• Aβ Peptide 14%

Biochemistry, Genetics and Molecular Biology

• Mammalian Target of Rapamycin 100%
• Transcription 100%
• Presenilin 100%
• Notch-1 100%
• Mechanistic Target of Rapamycin 71%
• Notch 42%
• Tau 14%
• Homeostasis 14%
• Mouse Model 14%
• Notch Signaling Pathway 14%
• Enzyme Active Site 14%
• Amyloid Precursor Protein 14%
• Gamma Secretase 14%
• Messenger RNA 14%

Neuroscience

• Notch 100%
• Presenilin 1 100%
• Mammalian Target of Rapamycin 71%
• Sirolimus 71%
• Alzheimer's Disease 28%
• Amyloid Precursor Protein 14%
• Notch Signaling Pathway 14%
• Cognitive Disorders 14%
• Notch1 Receptor 14%
• Enzyme Active Site 14%
• Amyloid Beta Protein 14%
• Gamma Secretase 14%
• Messenger RNA 14%