Inhibition of K ATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle

David Melvin Keller, Shigehiko Ogoh, Shane Greene, Albert Yurvati, Peter B. Raven

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In the present investigation we examined the role of ATP-sensitive potassium (K ATP ) channel activity in modulating carotid baroreflex (CBR)-induced vasoconstriction in the vasculature of the leg. The CBR control of mean arterial pressure (MAP) and leg vascular conductance (LVC) was determined in seven subjects (25 ± 1 years, mean ± S.E.M.) using the variable-pressure neck collar technique at rest and during one-legged knee extension exercise. The oral ingestion of glyburide (5 mg) did not change mean arterial pressure (MAP at rest (86 versus 89 mmHg, P > 0.05), but did appear to increase MAP during exercise (87 versus 92 mmHg, P = 0.053). However, the CBR-MAP function curves were similar at rest before and after glyburide ingestion. The CBR-mediated decrease in LVC observed at rest (∼39%) was attenuated during exercise in the exercising leg (∼15%, P < 0.05). Oral glyburide ingestion partially restored CBR-mediated vasoconstriction in the exercising leg (∼40% restoration, P < 0.05) compared to control exercise. These findings indicate that K ATP channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.

Original languageEnglish
Pages (from-to)273-282
Number of pages10
JournalJournal of Physiology
Volume561
Issue number1
DOIs
StatePublished - 15 Nov 2004

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Baroreflex
Vasoconstriction
Leg
Arterial Pressure
Skeletal Muscle
Adenosine Triphosphate
Glyburide
Eating
Blood Vessels
KATP Channels
Knee
Neck
Pressure

Cite this

Keller, David Melvin ; Ogoh, Shigehiko ; Greene, Shane ; Yurvati, Albert ; Raven, Peter B. / Inhibition of K ATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle In: Journal of Physiology. 2004 ; Vol. 561, No. 1. pp. 273-282.
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Inhibition of K ATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle . / Keller, David Melvin; Ogoh, Shigehiko; Greene, Shane; Yurvati, Albert; Raven, Peter B.

In: Journal of Physiology, Vol. 561, No. 1, 15.11.2004, p. 273-282.

Research output: Contribution to journalArticle

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