Abstract
In the present investigation we examined the role of ATP-sensitive potassium (KATP) channel activity in modulating carotid baroreflex (CBR)-induced vasoconstriction in the vasculature of the leg. The CBR control of mean arterial pressure (MAP) and leg vascular conductance (LVC) was determined in seven subjects (25 ± 1 years, mean ± S.E.M.) using the variable-pressure neck collar technique at rest and during one-legged knee extension exercise. The oral ingestion of glyburide (5 mg) did not change mean arterial pressure (MAP at rest (86 versus 89 mmHg, P > 0.05), but did appear to increase MAP during exercise (87 versus 92 mmHg, P = 0.053). However, the CBR-MAP function curves were similar at rest before and after glyburide ingestion. The CBR-mediated decrease in LVC observed at rest (∼39%) was attenuated during exercise in the exercising leg (∼15%, P < 0.05). Oral glyburide ingestion partially restored CBR-mediated vasoconstriction in the exercising leg (∼40% restoration, P < 0.05) compared to control exercise. These findings indicate that KATP channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.
| Original language | English |
|---|---|
| Pages (from-to) | 273-282 |
| Number of pages | 10 |
| Journal | Journal of Physiology |
| Volume | 561 |
| Issue number | 1 |
| DOIs | |
| State | Published - 15 Nov 2004 |
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Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle. / Keller, David Melvin; Ogoh, Shigehiko; Greene, Shane; Olivencia-Yurvati, A.; Raven, Peter B.
In: Journal of Physiology, Vol. 561, No. 1, 15.11.2004, p. 273-282.Research output: Contribution to journal › Article
TY - JOUR
T1 - Inhibition of KATP channel activity augments baroreflex-mediated vasoconstriction in exercising human skeletal muscle
AU - Keller, David Melvin
AU - Ogoh, Shigehiko
AU - Greene, Shane
AU - Olivencia-Yurvati, A.
AU - Raven, Peter B.
PY - 2004/11/15
Y1 - 2004/11/15
N2 - In the present investigation we examined the role of ATP-sensitive potassium (KATP) channel activity in modulating carotid baroreflex (CBR)-induced vasoconstriction in the vasculature of the leg. The CBR control of mean arterial pressure (MAP) and leg vascular conductance (LVC) was determined in seven subjects (25 ± 1 years, mean ± S.E.M.) using the variable-pressure neck collar technique at rest and during one-legged knee extension exercise. The oral ingestion of glyburide (5 mg) did not change mean arterial pressure (MAP at rest (86 versus 89 mmHg, P > 0.05), but did appear to increase MAP during exercise (87 versus 92 mmHg, P = 0.053). However, the CBR-MAP function curves were similar at rest before and after glyburide ingestion. The CBR-mediated decrease in LVC observed at rest (∼39%) was attenuated during exercise in the exercising leg (∼15%, P < 0.05). Oral glyburide ingestion partially restored CBR-mediated vasoconstriction in the exercising leg (∼40% restoration, P < 0.05) compared to control exercise. These findings indicate that KATP channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.
AB - In the present investigation we examined the role of ATP-sensitive potassium (KATP) channel activity in modulating carotid baroreflex (CBR)-induced vasoconstriction in the vasculature of the leg. The CBR control of mean arterial pressure (MAP) and leg vascular conductance (LVC) was determined in seven subjects (25 ± 1 years, mean ± S.E.M.) using the variable-pressure neck collar technique at rest and during one-legged knee extension exercise. The oral ingestion of glyburide (5 mg) did not change mean arterial pressure (MAP at rest (86 versus 89 mmHg, P > 0.05), but did appear to increase MAP during exercise (87 versus 92 mmHg, P = 0.053). However, the CBR-MAP function curves were similar at rest before and after glyburide ingestion. The CBR-mediated decrease in LVC observed at rest (∼39%) was attenuated during exercise in the exercising leg (∼15%, P < 0.05). Oral glyburide ingestion partially restored CBR-mediated vasoconstriction in the exercising leg (∼40% restoration, P < 0.05) compared to control exercise. These findings indicate that KATP channel activity modulates sympathetic vasoconstriction in humans and may prove to be an important mechanism by which functional sympatholysis operates in humans during exercise.
UR - http://www.scopus.com/inward/record.url?scp=9244231105&partnerID=8YFLogxK
U2 - 10.1113/jphysiol.2004.071993
DO - 10.1113/jphysiol.2004.071993
M3 - Article
C2 - 15345750
AN - SCOPUS:9244231105
VL - 561
SP - 273
EP - 282
JO - Journal of Physiology
JF - Journal of Physiology
SN - 0022-3751
IS - 1
ER -