Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration

Richard T. Libby, Michael G. Anderson, Iok Hou Pang, Zachary H. Robinson, Olga V. Savinova, I. Mihai Cosma, Amy Snow, Lawriston A. Wilson, Richard S. Smith, Abbot F. Clark, Simon W.M. John

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our updated findings from studying the disease in a large number of DBA/2J mice. The period when mice have elevated IOP extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice. Optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy.

Original languageEnglish
Pages (from-to)637-648
Number of pages12
JournalVisual Neuroscience
Volume22
Issue number5
DOIs
StatePublished - 1 Sep 2005

Fingerprint

Inbred DBA Mouse
Intraocular Pressure
Glaucoma
Retinal Ganglion Cells
Optic Nerve
Nerve Degeneration
Optic Nerve Diseases
Optic Disk
Neurodegenerative Diseases

Keywords

  • Glaucoma
  • Intraocular pressure
  • Mouse model
  • Neurodegeneration

Cite this

Libby, R. T., Anderson, M. G., Pang, I. H., Robinson, Z. H., Savinova, O. V., Cosma, I. M., ... John, S. W. M. (2005). Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration. Visual Neuroscience, 22(5), 637-648. https://doi.org/10.1017/S0952523805225130
Libby, Richard T. ; Anderson, Michael G. ; Pang, Iok Hou ; Robinson, Zachary H. ; Savinova, Olga V. ; Cosma, I. Mihai ; Snow, Amy ; Wilson, Lawriston A. ; Smith, Richard S. ; Clark, Abbot F. ; John, Simon W.M. / Inherited glaucoma in DBA/2J mice : Pertinent disease features for studying the neurodegeneration. In: Visual Neuroscience. 2005 ; Vol. 22, No. 5. pp. 637-648.
@article{8a39b457dafb4fcc99036955edc0759c,
title = "Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration",
abstract = "The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our updated findings from studying the disease in a large number of DBA/2J mice. The period when mice have elevated IOP extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice. Optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy.",
keywords = "Glaucoma, Intraocular pressure, Mouse model, Neurodegeneration",
author = "Libby, {Richard T.} and Anderson, {Michael G.} and Pang, {Iok Hou} and Robinson, {Zachary H.} and Savinova, {Olga V.} and Cosma, {I. Mihai} and Amy Snow and Wilson, {Lawriston A.} and Smith, {Richard S.} and Clark, {Abbot F.} and John, {Simon W.M.}",
year = "2005",
month = "9",
day = "1",
doi = "10.1017/S0952523805225130",
language = "English",
volume = "22",
pages = "637--648",
journal = "Visual Neuroscience",
issn = "0952-5238",
publisher = "Cambridge University Press",
number = "5",

}

Libby, RT, Anderson, MG, Pang, IH, Robinson, ZH, Savinova, OV, Cosma, IM, Snow, A, Wilson, LA, Smith, RS, Clark, AF & John, SWM 2005, 'Inherited glaucoma in DBA/2J mice: Pertinent disease features for studying the neurodegeneration', Visual Neuroscience, vol. 22, no. 5, pp. 637-648. https://doi.org/10.1017/S0952523805225130

Inherited glaucoma in DBA/2J mice : Pertinent disease features for studying the neurodegeneration. / Libby, Richard T.; Anderson, Michael G.; Pang, Iok Hou; Robinson, Zachary H.; Savinova, Olga V.; Cosma, I. Mihai; Snow, Amy; Wilson, Lawriston A.; Smith, Richard S.; Clark, Abbot F.; John, Simon W.M.

In: Visual Neuroscience, Vol. 22, No. 5, 01.09.2005, p. 637-648.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inherited glaucoma in DBA/2J mice

T2 - Pertinent disease features for studying the neurodegeneration

AU - Libby, Richard T.

AU - Anderson, Michael G.

AU - Pang, Iok Hou

AU - Robinson, Zachary H.

AU - Savinova, Olga V.

AU - Cosma, I. Mihai

AU - Snow, Amy

AU - Wilson, Lawriston A.

AU - Smith, Richard S.

AU - Clark, Abbot F.

AU - John, Simon W.M.

PY - 2005/9/1

Y1 - 2005/9/1

N2 - The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our updated findings from studying the disease in a large number of DBA/2J mice. The period when mice have elevated IOP extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice. Optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy.

AB - The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our updated findings from studying the disease in a large number of DBA/2J mice. The period when mice have elevated IOP extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice. Optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy.

KW - Glaucoma

KW - Intraocular pressure

KW - Mouse model

KW - Neurodegeneration

UR - http://www.scopus.com/inward/record.url?scp=27544501965&partnerID=8YFLogxK

U2 - 10.1017/S0952523805225130

DO - 10.1017/S0952523805225130

M3 - Article

C2 - 16332275

AN - SCOPUS:27544501965

VL - 22

SP - 637

EP - 648

JO - Visual Neuroscience

JF - Visual Neuroscience

SN - 0952-5238

IS - 5

ER -