Informativeness of the CODIS STR loci for admixture analysis

Jill S. Barnholtz-Sloan, Carrie L. Pfaff, Ranajit Chakraborty, Jeffrey C. Long

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Population admixture (or ancestry) is used as an approach to gene discovery in complex diseases, particularly when the disease prevalence varies widely across geographic populations. Admixture analysis could be useful for forensics because an indication of a perpetrator's ancestry would narrow the pool of suspects for a particular crime. The purpose of this study was to use Fisher's information to identify informative sets of markers for admixture analysis. Using published founding population allele frequencies we test three marker sets for efficacy for estimating admixture: the FBI CODIS Core STR loci, the HGDP-CEPH Human Genome Diversity Cell Line Panel and the set of 39 ancestry informative SNPS from the Shriver lab at Pennsylvania State University. We conclude that the FBI CODIS Core STR set is valid for admixture analysis, but not the most precise. We recommend using a combination of the most informative markers from the HGDP-CEPH and Shriver loci sets.

Original languageEnglish
Article numberJFS2003404
Pages (from-to)1322-1326
Number of pages5
JournalJournal of Forensic Sciences
Volume50
Issue number6
DOIs
StatePublished - Nov 2005

Keywords

  • Admixture analysis
  • Ancestry
  • CODIS STR loci
  • Forensic science
  • Population admixture

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    Barnholtz-Sloan, J. S., Pfaff, C. L., Chakraborty, R., & Long, J. C. (2005). Informativeness of the CODIS STR loci for admixture analysis. Journal of Forensic Sciences, 50(6), 1322-1326. [JFS2003404]. https://doi.org/10.1520/jfs2003404