@article{d3118ce5f6cf4b51b5476c8d3e01e19d,
title = "Influence of pretreatment with tobacco smoke condensate or 3-methylcholanthrene on [14C] benzo (A) pyrene metabolism in the isolated perfused rabbit lung",
abstract = "Pretreatment 24 h before sacrifice with i.p. tobacco smoke condensate (TSC) or 3-methylcholanthrene (3MC) increased the rate of disappearance of [14C]benzo(a)pyrene (BP) from an isolated perfused rabbit lung model. Both pretreatments significantly increased the amount of most metabolites formed. This study indicates that rabbits tend to resemble rats, mice and hamsters in that increased rates of pulmonary BP metabolism are a consequence of exposure to TSC.",
author = "Lubawy, {William C.} and Isaac, {Ramdas S.}",
note = "Funding Information: This investigation was supported (in part) by University of Kentucky Tobacco and Health Research Institute Project No. KTRB 24098. The authors gratefully acknowledge Ms. G. Maggard for technical assistance and Dr. D. Haack of the Kentucky Tobacco and Health Research Institute for performing the statistical analysis.",
year = "1980",
month = dec,
doi = "10.1016/0378-4274(80)90049-1",
language = "English",
volume = "7",
pages = "153--159",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",
number = "2",
}