Influence of pretreatment with tobacco smoke condensate or 3-methylcholanthrene on [14C] benzo (A) pyrene metabolism in the isolated perfused rabbit lung

William C. Lubawy, Ramdas S. Isaac

Research output: Contribution to journalArticle

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Abstract

Pretreatment 24 h before sacrifice with i.p. tobacco smoke condensate (TSC) or 3-methylcholanthrene (3MC) increased the rate of disappearance of [14C]benzo(a)pyrene (BP) from an isolated perfused rabbit lung model. Both pretreatments significantly increased the amount of most metabolites formed. This study indicates that rabbits tend to resemble rats, mice and hamsters in that increased rates of pulmonary BP metabolism are a consequence of exposure to TSC.

Original languageEnglish
Pages (from-to)153-159
Number of pages7
JournalToxicology Letters
Volume7
Issue number2
DOIs
Publication statusPublished - Dec 1980

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