Inflammatory biomarkers, depressive symptoms and falls among the elderly in panama

Gabrielle B. Britton, Sid E. O’bryant, Leigh A. Johnson, James R. Hall, Alcibiades E. Villarreal, Diana C. Oviedo, Ambar R. Pérez-Lao, María B. Carreira

Research output: Contribution to journalArticle

Abstract

Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.

Original languageEnglish
Pages (from-to)236-241
Number of pages6
JournalCurrent Aging Science
Volume11
Issue number4
DOIs
StatePublished - 1 Jan 2018

Fingerprint

Panama
Interleukin-7
Biomarkers
Depression
Activities of Daily Living
Hispanic Americans
Inflammation
Institutionalization
Interleukin-1
Research
Geriatrics
Interleukin-10
C-Reactive Protein
Cognition
Interleukin-6
Hospitalization
Public Health
Logistic Models
Guidelines
T-Lymphocytes

Keywords

  • Aging
  • Depression
  • Disability
  • Hispanics
  • Inflammation
  • Latin America

Cite this

Britton, Gabrielle B. ; O’bryant, Sid E. ; Johnson, Leigh A. ; Hall, James R. ; Villarreal, Alcibiades E. ; Oviedo, Diana C. ; Pérez-Lao, Ambar R. ; Carreira, María B. / Inflammatory biomarkers, depressive symptoms and falls among the elderly in panama. In: Current Aging Science. 2018 ; Vol. 11, No. 4. pp. 236-241.
@article{4d7155dca83b4caf9bbef5e0025f9ebb,
title = "Inflammatory biomarkers, depressive symptoms and falls among the elderly in panama",
abstract = "Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.",
keywords = "Aging, Depression, Disability, Hispanics, Inflammation, Latin America",
author = "Britton, {Gabrielle B.} and O’bryant, {Sid E.} and Johnson, {Leigh A.} and Hall, {James R.} and Villarreal, {Alcibiades E.} and Oviedo, {Diana C.} and P{\'e}rez-Lao, {Ambar R.} and Carreira, {Mar{\'i}a B.}",
year = "2018",
month = "1",
day = "1",
doi = "10.2174/1874609812666190215125104",
language = "English",
volume = "11",
pages = "236--241",
journal = "Current aging science",
issn = "1874-6098",
publisher = "Bentham Science Publishers",
number = "4",

}

Inflammatory biomarkers, depressive symptoms and falls among the elderly in panama. / Britton, Gabrielle B.; O’bryant, Sid E.; Johnson, Leigh A.; Hall, James R.; Villarreal, Alcibiades E.; Oviedo, Diana C.; Pérez-Lao, Ambar R.; Carreira, María B.

In: Current Aging Science, Vol. 11, No. 4, 01.01.2018, p. 236-241.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inflammatory biomarkers, depressive symptoms and falls among the elderly in panama

AU - Britton, Gabrielle B.

AU - O’bryant, Sid E.

AU - Johnson, Leigh A.

AU - Hall, James R.

AU - Villarreal, Alcibiades E.

AU - Oviedo, Diana C.

AU - Pérez-Lao, Ambar R.

AU - Carreira, María B.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.

AB - Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality. Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults. Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. A non-fasting blood sample was obtained. Self-reported falls were classified as no falls, single falls or recurrent (two or more) falls reported in the 12 months prior to baseline evaluations. Serum levels of C Reactive Protein (CRP), T-lymphocyte secreting protein (I-309), interleukin 10 (IL-10), interleukin 6 (IL-6) and interleukin 7 (IL-7) were measured. Global cognition was assessed with the Mini Mental State Examination and depressive symptoms were assessed with the Geriatric Depression Scale (GDS-30). Multinomial logistic regression was used to assess the link between inflammation and fall events. Results: Depressive symptoms, limitations in Instrumental Activities of Daily Living (IADL), IL-7 and I-309 were significantly related to fall events. Elevated levels of IL-7 increased the likelihood of single and recurrent falls, while increased levels of I-309 were associated only with recurrent falls. Greater IADL limitations and depressive symptoms were associated with an increased likelihood of recurrent falls. Conclusion: There is a lack of research investigating the relationship between inflammatory biomarkers and fall events. These results provide evidence of risk factors for falls in Hispanic older adults, and could serve to guide public health professionals to establish clinical guidelines to reduce fall risks.

KW - Aging

KW - Depression

KW - Disability

KW - Hispanics

KW - Inflammation

KW - Latin America

UR - http://www.scopus.com/inward/record.url?scp=85065813073&partnerID=8YFLogxK

U2 - 10.2174/1874609812666190215125104

DO - 10.2174/1874609812666190215125104

M3 - Article

C2 - 30767759

AN - SCOPUS:85065813073

VL - 11

SP - 236

EP - 241

JO - Current aging science

JF - Current aging science

SN - 1874-6098

IS - 4

ER -