Infinite allele model with varying mutation rate

M. Nel, R. Chakraborty, P. A. Fuerst

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.

Original languageEnglish
Pages (from-to)4164-4168
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number11
StatePublished - 1976


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