TY - JOUR
T1 - Infinite allele model with varying mutation rate
AU - Nel, M.
AU - Chakraborty, R.
AU - Fuerst, P. A.
PY - 1976
Y1 - 1976
N2 - Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.
AB - Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.
UR - http://www.scopus.com/inward/record.url?scp=0017101349&partnerID=8YFLogxK
U2 - 10.1073/pnas.73.11.4164
DO - 10.1073/pnas.73.11.4164
M3 - Article
C2 - 1069306
AN - SCOPUS:0017101349
SN - 0027-8424
VL - 73
SP - 4164
EP - 4168
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 11
ER -