Abstract

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and the human eye; development of improved methods to induce glaucoma and to evaluate glaucomatous damage; availability of genetic tools in the mouse; as well as the relatively low cost of rodent studies. Commonly studied rat and mouse glaucoma models include intraocular pressure (IOP)-dependent and pressure-independent models. The pressure-dependent models address the most important risk factor of elevated IOP, whereas the pressure-independent models assess “normal tension” glaucoma and other “non-IOP” related factors associated with glaucomatous damage. The current article provides descriptions of these models, their characterizations, specific techniques to induce glaucoma, mechanisms of injury, advantages, and limitations.

Original languageEnglish
Article number100799
JournalProgress in Retinal and Eye Research
DOIs
StateAccepted/In press - 1 Jan 2019

Fingerprint

Glaucoma
Rodentia
Pressure
Intraocular Pressure
Low Tension Glaucoma
Animal Models
Costs and Cost Analysis
Wounds and Injuries
Research
Therapeutics

Keywords

  • Animal model
  • Glaucoma
  • In vivo
  • Intraocular pressure
  • Pathogenesis
  • Rodent

Cite this

@article{1c474aad498345558be9b68460790e75,
title = "Inducible rodent models of glaucoma",
abstract = "Glaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and the human eye; development of improved methods to induce glaucoma and to evaluate glaucomatous damage; availability of genetic tools in the mouse; as well as the relatively low cost of rodent studies. Commonly studied rat and mouse glaucoma models include intraocular pressure (IOP)-dependent and pressure-independent models. The pressure-dependent models address the most important risk factor of elevated IOP, whereas the pressure-independent models assess “normal tension” glaucoma and other “non-IOP” related factors associated with glaucomatous damage. The current article provides descriptions of these models, their characterizations, specific techniques to induce glaucoma, mechanisms of injury, advantages, and limitations.",
keywords = "Animal model, Glaucoma, In vivo, Intraocular pressure, Pathogenesis, Rodent",
author = "Pang, {Iok Hou} and Clark, {Abbot F.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.preteyeres.2019.100799",
language = "English",
journal = "Progress in Retinal and Eye Research",
issn = "1350-9462",
publisher = "Elsevier Ltd",

}

Inducible rodent models of glaucoma. / Pang, Iok Hou; Clark, Abbot F.

In: Progress in Retinal and Eye Research, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inducible rodent models of glaucoma

AU - Pang, Iok Hou

AU - Clark, Abbot F.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Glaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and the human eye; development of improved methods to induce glaucoma and to evaluate glaucomatous damage; availability of genetic tools in the mouse; as well as the relatively low cost of rodent studies. Commonly studied rat and mouse glaucoma models include intraocular pressure (IOP)-dependent and pressure-independent models. The pressure-dependent models address the most important risk factor of elevated IOP, whereas the pressure-independent models assess “normal tension” glaucoma and other “non-IOP” related factors associated with glaucomatous damage. The current article provides descriptions of these models, their characterizations, specific techniques to induce glaucoma, mechanisms of injury, advantages, and limitations.

AB - Glaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Key reasons are: many important biological similarities shared among rodent eyes and the human eye; development of improved methods to induce glaucoma and to evaluate glaucomatous damage; availability of genetic tools in the mouse; as well as the relatively low cost of rodent studies. Commonly studied rat and mouse glaucoma models include intraocular pressure (IOP)-dependent and pressure-independent models. The pressure-dependent models address the most important risk factor of elevated IOP, whereas the pressure-independent models assess “normal tension” glaucoma and other “non-IOP” related factors associated with glaucomatous damage. The current article provides descriptions of these models, their characterizations, specific techniques to induce glaucoma, mechanisms of injury, advantages, and limitations.

KW - Animal model

KW - Glaucoma

KW - In vivo

KW - Intraocular pressure

KW - Pathogenesis

KW - Rodent

UR - http://www.scopus.com/inward/record.url?scp=85073825401&partnerID=8YFLogxK

U2 - 10.1016/j.preteyeres.2019.100799

DO - 10.1016/j.preteyeres.2019.100799

M3 - Article

C2 - 31557521

AN - SCOPUS:85073825401

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

SN - 1350-9462

M1 - 100799

ER -