Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise

K. M. Gallagher, P. J. Fadel, S. A. Smith, K. H. Norton, R. G. Querry, Albert Yurvati, P. B. Raven

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

This investigation was designed to determine the role of intramuscular pressure-sensitive mechanoreceptors and chemically sensitive metaboreceptors in affecting the blood pressure response to dynamic exercise in humans. Sixteen subjects performed incremental (20 W/min) cycle exercise to fatigue under four conditions: control, exercise with thigh cuff occlusion of 90 Torr (Cuff occlusion), exercise with lower body positive pressure (LBPP) of 45 Torr, and a combination of thigh cuff occlusion and LBPP (combination). Indexes of central command (heart rate, oxygen uptake, ratings of perceived exertion, and electromyographic activity), cardiac output, stroke volume, and total peripheral resistance were not significantly different between the four conditions. Mechanical stimulation during LBPP and combination conditions resulted in significant elevations in intramuscular pressure and mean arterial pressure from control at rest and throughout the incremental exercise protocol (P < 0.05). Conversely, there existed no significant changes in mean arterial pressure when the metaboreflex was stimulated by cuff occlusion. These findings suggest that under normal conditions the mechanoreflex is tonically active and is the primary mediator of exercise pressor reflex-induced alterations in arterial blood pressure during submaximal dynamic exercise in humans.

Original languageEnglish
Pages (from-to)2351-2358
Number of pages8
JournalJournal of Applied Physiology
Volume91
Issue number5
StatePublished - 10 Nov 2001

Fingerprint

Arterial Pressure
Pressure
Thigh
Mechanoreceptors
Cardiac Output
Vascular Resistance
Stroke Volume
Fatigue
Reflex
Heart Rate
Oxygen
Blood Pressure

Keywords

  • Exercise pressor reflex
  • Mechanoreceptors
  • Metaboreceptors

Cite this

Gallagher, K. M., Fadel, P. J., Smith, S. A., Norton, K. H., Querry, R. G., Yurvati, A., & Raven, P. B. (2001). Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise. Journal of Applied Physiology, 91(5), 2351-2358.
Gallagher, K. M. ; Fadel, P. J. ; Smith, S. A. ; Norton, K. H. ; Querry, R. G. ; Yurvati, Albert ; Raven, P. B. / Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise. In: Journal of Applied Physiology. 2001 ; Vol. 91, No. 5. pp. 2351-2358.
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Gallagher, KM, Fadel, PJ, Smith, SA, Norton, KH, Querry, RG, Yurvati, A & Raven, PB 2001, 'Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise', Journal of Applied Physiology, vol. 91, no. 5, pp. 2351-2358.

Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise. / Gallagher, K. M.; Fadel, P. J.; Smith, S. A.; Norton, K. H.; Querry, R. G.; Yurvati, Albert; Raven, P. B.

In: Journal of Applied Physiology, Vol. 91, No. 5, 10.11.2001, p. 2351-2358.

Research output: Contribution to journalArticleResearchpeer-review

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Gallagher KM, Fadel PJ, Smith SA, Norton KH, Querry RG, Yurvati A et al. Increases in intramuscular pressure raise arterial blood pressure during dynamic exercise. Journal of Applied Physiology. 2001 Nov 10;91(5):2351-2358.