Increased severity of stroke in CB1 cannabinoid receptor knock-out mice

Sophie Parmentier-Batteur, Kunlin Jin, Xiao Ou Mao, Lin Xie, David A. Greenberg

Research output: Contribution to journalArticlepeer-review

206 Scopus citations


Endogenous cannabinoid signaling pathways have been implicated in protection of the brain from hypoxia, ischemia, and trauma, but the mechanism for these protective effects is uncertain. We found that in CB1 cannabinoid receptor knock-out mice, mortality from permanent focal cerebral ischemia was increased, infarct size and neurological deficits after transient focal cerebral ischemia were more severe, cerebral blood flow in the ischemic penumbra during reperfusion was reduced, and NMDA neurotoxicity was increased compared with wild-type littermates. These findings indicate that endogenous cannabinoid signaling pathways protect mice from ischemic stroke by a mechanism that involves CB1 receptors, and suggest that both blood vessels and neurons may be targets of this protective effect.

Original languageEnglish
Pages (from-to)9771-9775
Number of pages5
JournalJournal of Neuroscience
Issue number22
StatePublished - 15 Nov 2002


  • CB1
  • Cannabinoid
  • Cerebral blood flow
  • Ischemia
  • NMDA
  • Receptor
  • Stroke


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