Abstract
DNA detection is usually performed using fluorescence probes. Using a DNA oligomer stained with the widely used dye 1,1′ -[1,3-propanediylbis[(dimethylimino)-3,1-propanediyl]]-bis[4-[(3-methyl-2(3H) -benzoxazolylidene)methyl]]-quinolinum tetraiodide (YOYO-1), we show that a substrate containing silver particles can lead to a greater than 10-fold increase in the fluorescence intensity. Proximity to silver particles also increases the photostability of YOYO-1-DNA. These results suggest that substrates or gels containing silver particles may be used for increased sensitivity in DNA detection.
Original language | English |
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Pages (from-to) | 604-607 |
Number of pages | 4 |
Journal | Photochemistry and Photobiology |
Volume | 77 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2003 |