Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin

Salomon A. Stavchansky, William C. Lubawy, Harry B. Kostenbauder

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The major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, has been shown to inhibit hexobarbital and ethylmorphine metabolism by a rat liver homogenate, and to markedly prolong hexobarbital sleeping time in mice. Such cross-inhibition of metabolism among drugs which are detoxified by formation of hydroxylated metabolites represents an example of a drug-drug interaction which must be taken into account when describing the behavior of drugs in the body.

Original languageEnglish
Pages (from-to)1535-1539
Number of pages5
JournalLife Sciences
Issue number8
Publication statusPublished - 16 Apr 1974


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