Abstract
The major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, has been shown to inhibit hexobarbital and ethylmorphine metabolism by a rat liver homogenate, and to markedly prolong hexobarbital sleeping time in mice. Such cross-inhibition of metabolism among drugs which are detoxified by formation of hydroxylated metabolites represents an example of a drug-drug interaction which must be taken into account when describing the behavior of drugs in the body.
Original language | English |
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Pages (from-to) | 1535-1539 |
Number of pages | 5 |
Journal | Life Sciences |
Volume | 14 |
Issue number | 8 |
DOIs | |
State | Published - 16 Apr 1974 |