Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin

Salomon A. Stavchansky; William C. Lubawy; Harry B. Kostenbauder

doi:10.1016/0024-3205(74)90164-7

Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin

Salomon A. Stavchansky, William C. Lubawy, Harry B. Kostenbauder

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, has been shown to inhibit hexobarbital and ethylmorphine metabolism by a rat liver homogenate, and to markedly prolong hexobarbital sleeping time in mice. Such cross-inhibition of metabolism among drugs which are detoxified by formation of hydroxylated metabolites represents an example of a drug-drug interaction which must be taken into account when describing the behavior of drugs in the body.

Original language	English
Pages (from-to)	1535-1539
Number of pages	5
Journal	Life Sciences
Volume	14
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(74)90164-7
State	Published - 16 Apr 1974

Access to Document

10.1016/0024-3205(74)90164-7

Cite this

@article{4d8d0fc5de7048cc9f9f2505929f5f64,

title = "Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin",

abstract = "The major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, has been shown to inhibit hexobarbital and ethylmorphine metabolism by a rat liver homogenate, and to markedly prolong hexobarbital sleeping time in mice. Such cross-inhibition of metabolism among drugs which are detoxified by formation of hydroxylated metabolites represents an example of a drug-drug interaction which must be taken into account when describing the behavior of drugs in the body.",

author = "Stavchansky, {Salomon A.} and Lubawy, {William C.} and Kostenbauder, {Harry B.}",

year = "1974",

month = apr,

day = "16",

doi = "10.1016/0024-3205(74)90164-7",

language = "English",

volume = "14",

pages = "1535--1539",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "8",

}

TY - JOUR

T1 - Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin

AU - Stavchansky, Salomon A.

AU - Lubawy, William C.

AU - Kostenbauder, Harry B.

PY - 1974/4/16

Y1 - 1974/4/16

N2 - The major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, has been shown to inhibit hexobarbital and ethylmorphine metabolism by a rat liver homogenate, and to markedly prolong hexobarbital sleeping time in mice. Such cross-inhibition of metabolism among drugs which are detoxified by formation of hydroxylated metabolites represents an example of a drug-drug interaction which must be taken into account when describing the behavior of drugs in the body.

AB - The major metabolite of diphenylhydantoin, 5-(p-hydroxyphenyl)-5-phenylhydantoin, has been shown to inhibit hexobarbital and ethylmorphine metabolism by a rat liver homogenate, and to markedly prolong hexobarbital sleeping time in mice. Such cross-inhibition of metabolism among drugs which are detoxified by formation of hydroxylated metabolites represents an example of a drug-drug interaction which must be taken into account when describing the behavior of drugs in the body.

UR - http://www.scopus.com/inward/record.url?scp=0016394818&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(74)90164-7

DO - 10.1016/0024-3205(74)90164-7

M3 - Article

C2 - 4829543

AN - SCOPUS:0016394818

SN - 0024-3205

VL - 14

SP - 1535

EP - 1539

JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Increase of hexobarbital sleeping time and inhibition of drug metabolism by the major metabolite of diphenylhydantoin

Abstract

Access to Document

Other files and links

Fingerprint

Cite this