In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin

William Charles Lubawy, H. B. Kostenbauder, J. P. McGovren

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2 Citations (Scopus)

Abstract

The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.

Original languageEnglish
Pages (from-to)257-269
Number of pages13
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume19
Issue number2
StatePublished - 1 Jan 1978

Fingerprint

Phenytoin
Metabolites
Nicotine
Metabolism
Cotinine
Liver
Rats
In Vitro Techniques
2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a
nicotine 1-N-oxide

Cite this

Lubawy, William Charles ; Kostenbauder, H. B. ; McGovren, J. P. / In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin. In: Research Communications in Chemical Pathology and Pharmacology. 1978 ; Vol. 19, No. 2. pp. 257-269.
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In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin. / Lubawy, William Charles; Kostenbauder, H. B.; McGovren, J. P.

In: Research Communications in Chemical Pathology and Pharmacology, Vol. 19, No. 2, 01.01.1978, p. 257-269.

Research output: Contribution to journalArticleResearchpeer-review

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