The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.
|Number of pages||13|
|Journal||Research Communications in Chemical Pathology and Pharmacology|
|Publication status||Published - 1 Jan 1978|