In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin

W. C. Lubawy; H. B. Kostenbauder; J. P. McGovren

In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin

W. C. Lubawy, H. B. Kostenbauder, J. P. McGovren

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.

Original language	English
Pages (from-to)	257-269
Number of pages	13
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	19
Issue number	2
State	Published - 1978

Cite this

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title = "In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin",

abstract = "The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.",

author = "Lubawy, {W. C.} and Kostenbauder, {H. B.} and McGovren, {J. P.}",

year = "1978",

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AU - Kostenbauder, H. B.

AU - McGovren, J. P.

PY - 1978

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N2 - The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.

AB - The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.

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AN - SCOPUS:0017843630

SN - 0034-5164

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JF - RES.COMMUN.CHEM.PATH.PHARMACOL.

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ER -

In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin

Abstract

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