Abstract
The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.
Original language | English |
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Pages (from-to) | 257-269 |
Number of pages | 13 |
Journal | Research Communications in Chemical Pathology and Pharmacology |
Volume | 19 |
Issue number | 2 |
State | Published - 1978 |