In vivo and in vitro alteration of nicotine metabolism by the major metabolite of phenytoin

William Charles Lubawy, H. B. Kostenbauder, J. P. McGovren

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The influence of hydroxyphenytoin (HPPH), the major metabolite of phenytoin, on the in vitro and in vivo metabolism of nicotine was examined. In rat liver 9,000 g supernatant HPPH decreased the appearance of cotinine from nicotine by 65% while not influencing the disappearance of nicotine or the appearance of nicotine-1' -N-oxide. In vivo, HPPH inhibited both nicotine elimination and cotinine formation but did not affect nicotine-1' -N-oxide formation.

Original languageEnglish
Pages (from-to)257-269
Number of pages13
JournalResearch Communications in Chemical Pathology and Pharmacology
Issue number2
Publication statusPublished - 1 Jan 1978


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