In vitro differentiation potential of mesenchymal stem cells

Jeffrey M. Gimble, Farshid Guilak, Mark E. Nuttall, Solomon Sathishkumar, Martin Vidal, Bruce A. Bunnell

Research output: Contribution to journalReview articlepeer-review

93 Scopus citations


Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

Original languageEnglish
Pages (from-to)228-238
Number of pages11
JournalTransfusion Medicine and Hemotherapy
Issue number3
StatePublished - Jun 2008


  • Adipose-derived stem cells
  • Differentiation
  • Mesenchymal stem cells


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