In vitro differentiation potential of mesenchymal stem cells

Jeffrey M. Gimble, Farshid Guilak, Mark E. Nuttall, Solomon Sathishkumar, Martin Vidal, Bruce A. Bunnell

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

Original languageEnglish
Pages (from-to)228-238
Number of pages11
JournalTransfusion Medicine and Hemotherapy
Volume35
Issue number3
DOIs
StatePublished - Jun 2008

Keywords

  • Adipose-derived stem cells
  • Differentiation
  • Mesenchymal stem cells

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