Immunology and Microbiology
Biological Activity
100%
Cell Line
50%
Normal Human
50%
Cell Proliferation
50%
Cancer Cell Line
50%
Biological Functions
50%
Tumor Cell Line
50%
Cell Cycle Checkpoint
50%
Cell Cycle Arrest
50%
Antineoplastic Activity
50%
Competitive Inhibition
50%
Chromosome Segregation
50%
Mitosis Spindle
50%
Lung Adenocarcinoma Cell Line
50%
Diploidy
50%
Fibroblast
50%
Keyphrases
Small Molecule Inhibitors
100%
In Vitro Activity
100%
Polo-like Kinase 1 (PLK1)
100%
Apoptosis
33%
PLK3
33%
Normal Human
11%
In Cancer
11%
Tumor Cell Lines
11%
Human Diploid Fibroblasts
11%
Therapeutic Agents
11%
Cell Cycle Arrest
11%
Poor Prognosis
11%
Proliferating Cells
11%
Trifluoromethyl
11%
High-level Expression
11%
Cancer Cell Lines
11%
Chromosome Segregation
11%
Biological Function
11%
Mitotic Spindle
11%
Benzyl
11%
Antitumor Activity in Vivo
11%
Mechanistic Assays
11%
Thiophene
11%
Thiophene-2-carbaldehyde
11%
1H-benzimidazole
11%
Mitotic Entry
11%
Cytokinesis
11%
Cell Line Activity
11%
Benzimidazole
11%
ATP-competitive Inhibitors
11%
Tumor Expression
11%
Normal Cell Line
11%
G2-M Arrest
11%
Lung Adenocarcinoma Cells
11%
Multinucleated
11%
Spindle Formation
11%
Spindle Defects
11%
NCI-H460
11%
Mitotic Progression
11%
Nanomolar Activity
11%
Biochemistry, Genetics and Molecular Biology
Small Molecule
100%
Biological Activity
100%
Polo-Like Kinase 1
100%
Thiophene
22%
Cancer Cell
11%
Cell Proliferation
11%
Normal Human
11%
Adenosine Triphosphate
11%
Enzyme
11%
Competitive Inhibition
11%
Cell Cycle Arrest
11%
Cell Cycle Checkpoint
11%
Chromosome Segregation
11%
Biological Functions
11%
Antineoplastic Activity
11%
Mitosis Spindle
11%
Diploidy
11%
Fibroblast
11%
Pharmacology, Toxicology and Pharmaceutical Science
Biological Activity
100%
Polo Like Kinase 1
100%
Malignant Neoplasm
22%
Neoplasm
22%
Thiophene
22%
Adenosine Triphosphate
11%
Normal Human
11%
Carboxamide
11%
Antitumor Activity
11%
Lung Adenocarcinoma
11%
Competitive Inhibitor
11%
Benzimidazole
11%