In vitro and in vivo activities of novel 6-methylidene penems as β-lactamase inhibitors

Keyphrases

• Bacterial Infection 14%
• Citrobacter 14%
• Clearance Rate 14%
• Enterobacter 14%
• Enzyme Activity 14%
• ESBL-E. Coli 14%
• ESBL-producing 14%
• Extended-spectrum-lactamase 14%
• Heterocycles 14%
• Hydrolysis 14%
• Imipenem 14%
• In Vivo Activity 100%
• Inhibition Rate 14%
• Intravenous Administration 14%
• Klebsiella Pneumoniae (K. pneumoniae) 14%
• Mean Residence Time 14%
• Median Effective Dose 14%
• Metalloenzymes 14%
• Methylidene 100%
• MIC Determination 14%
• Penem 100%
• Pharmacokinetic Analysis 14%
• Piperacillin 100%
• Serratia 14%
• TEM-1 14%
• Therapeutic Agents 14%
• Volume of Distribution 14%
• β-lactam Antibiotics 14%
• β-lactamase 14%
• β-lactamase Inhibitor 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Bacterial Infection 14%
• Beta Lactam Antibiotic 14%
• Beta Lactamase TEM 1 14%
• Citrobacter 14%
• Enterobacter 14%
• Escherichia Coli Pneumonia 14%
• Extended Spectrum Beta Lactamase 14%
• Extended Spectrum Beta Lactamase Producing Escherichia Coli 14%
• Imipenem 14%
• Klebsiella pneumoniae 14%
• Penicillinase 100%
• Pharmacokinetics 14%
• Piperacillin 100%
• Serratia 14%
• Volume of Distribution 14%